江西科学2024，Vol.42Issue(2)：257-263,7.DOI:10.13990/j.issn1001-3679.2024.02.007
短链脂肪酸促进痛风炎症反应消散作用的研究进展
Research Progress of Short-chain Fatty Acids Promoting the Dissipation of Gout Inflammatory Response
摘要
Abstract
Objective:The aim of this paper is to provide a systematic overview of the role of short chain fatty acids(SCFAs)in the dissipation of the inflammatory response in gout,in order to pro-vide a theoretical basis for clinical diagnosis and treatment.Methods:we explored the mechanism of SCFAs,the end products of dietary fiber fermentation by intestinal flora,in promoting the dissipa-tion of gout inflammatory response from metabolic receptors,signaling pathways and intestinal barri-ers by using literature search and review.Results:SCFAs bind to G protein-coupled receptor(GPR43)with different affinities,reduce pro-inflammatory cytokine production,and attenuate the inflammatory response by inhibiting the MAPK/NF-КB signaling pathway.In addition,SCFAs ac-ted directly on intestinal epithelial cells to maintain the integrity of the intestinal mucosal barrier and prevent the invasion of pathogenic bacteria.Conclusion:The results suggest that SCFAs play an im-portant role in the dissipation of inflammatory response in gout,mainly through reducing pro-inflam-matory factor production,inhibiting inflammatory signaling pathways,and maintaining intestinal bar-rier integrity.SCFAs are expected to be a potential therapeutic target for the clinical treatment of gout,providing new possibilities for the clinical treatment of gout.关键词
痛风/炎症反应/短链脂肪酸/肠黏膜屏障Key words
gout/inflammatory response/short-chain fatty acids/intestinal mucosal barrier分类
医药卫生引用本文复制引用
邓曼琦,顾兵,吴思颖,李华南..短链脂肪酸促进痛风炎症反应消散作用的研究进展[J].江西科学,2024,42(2):257-263,7.基金项目
国家自然科学基金资助项目(82060871) （82060871）
江西省自然科学基金项目(20232ACB206051) （20232ACB206051）
江西省高等学校大学生创新创业训练计划项目(202311318026X) （202311318026X）
江西省中医药管理局重点研究室、临床研究基地(第三批)建设项目(赣中医药科教字(2022)8号) （第三批）
中医优势专病专科项目-痛风(赣中医药综合字[2022]4号). （赣中医药综合字[2022]4号）
