2型糖尿病患者血清γ-谷氨酰转移酶与颈动脉粥样硬化的关联性OACSTPCD

Objective To investigate the association between serum γ-glutamyltransferase(GGT)and ca-rotid atherosclerosis(CAS)in patients with type 2 diabetes mellitus(T2DM)using observational study and Mendelian randomization(MR)analysis.Methods A total of 354 patients with T2DM who met the diagnostic criteria and were admitted to the Department of Endocrinology of the hospital from January 2020 to June 2023 were selected as the research objects.Among them,247 patients with CAS were selected as the CAS group,and 107 patients without CAS were selected as the non-CAS group.Based on the pooled data from genome-wide association studies,two-sample MR was used to explore the causal association between GGT and CAS.The inverse variance weighting(IVW)method was used as the main analysis method,supplemented by MR-Egger regression and weighted median method.Heterogeneity test,pleiotropy test and exclusion test were used for further sensitivity analysis.Results There was no significant difference in serum GGT levels between the CAS group and the non-CAS group(P>0.05).IVW results did not support a causal effect between serum GGT level and CAS(GGT→carotid intima-media thickness:P=0.423,GGT→AS:P=0.345).The results of MR-Egger regression method and WM were consistent with IVW,and did not support a causal effect between serum GGT level and CAS.The results of pleiotropy test showed that there was no horizontal pleiotropy(GGT→carotid intima-media thickness:MR-Egger regression intercept=0.00,P=0.262,GGT→AS:MR-Egger regression intercept=0.00,P=0.059).Conclusion The results of both observational studies and MR Analysis do not support a causal association between serum GGT levels and CAS.