血清微管解聚蛋白、CHI3L1与非小细胞肺癌患者肺癌根治术后复发转移的关系OACSTPCD

Objective To investigate the relationship between serum microtubule depolymerization protein and chitinase 3-like protein 1(CHI3L1)and recurrence and metastasis in patients with non-small cell lung cancer(NSCLC)after radical lung cancer surgery.Methods A total of 153 patients with NSCLC who under-went radical lung cancer surgery of lung cancer in Xianyang Hospital of Yan'an University from January 2017 to January 2020 were selected as the research objects.Enzyme-linked immunosorbent assay was used to detect the serum levels of microtubule disintegrin and CHI3L1 before surgery.According to the recurrence and me-tastasis of NSCLC patients after radical lung cancer surgery,they were divided into recurrence and metastasis group and non-recurrence and metastasis group.The general data and serum levels of microtubule depolymer-ization protein and CHI3L1 were compared between the two groups.Multivariate Logistic regression was used to analyze the influencing factors of recurrence and metastasis in NSCLC patients after radical lung cancer sur-gery.The receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of serum microtubule depolymerization protein and CHI3L1 for postoperative recurrence and metastasis in NSCLC pa-tients after radical lung cancer surgery.Results Among the 153 patients,49 patients had recurrence and me-tastasis they were included in the recurrence and metastasis group,and 104 patients did not have recurrence and metastasis,and were included in the non-recurrence and metastasis group.The proportion of patients with maximum diameter of tumor≥5 cm,TNM stage ⅢA,low differentiation,lymph node metastasis,non postop-erative adjuvant chemotherapy,CA125 level,serum microtubule depolymerization protein level,and serum CHI3L1 level in the recurrence and metastasis group were higher than those in the non-recurrence and metas-tasis group,and the differences were statistically significant(P<0.05).Multivariate Logistic regression anal-ysis showed that TNM stage ⅢA,lymph node metastasis,elevated serum levels of microtubule depolymeriza-tion protein and CHI3L1 were independent risk factors for recurrence and metastasis of NSCLC patients after radical lung cancer surgery(P<0.05).The area under the curve of serum microtubule depolymerization pro-tein,CHI3L1 and their combination for predicting recurrence and metastasis of NSCLC patients after radical lung cancer surgery were 0.841,0.763 and 0.918 respectively.The predictive value of combined detection of the two indicators was better than that of the two indicators alone(P<0.05).Conclusion Elevated serum microtubule depolymerization protein and CHI3L1 levels are both independent risk factors for recurrence and metastasis of NSCLC patients after radical lung cancer surgery.The combined detection of the two indicators has a high predictive value for recurrence and metastasis of NSCLC patients after radical lung cancer surgery.