检验医学与临床2024，Vol.21Issue(8)：1092-1095,1102,5.DOI:10.3969/j.issn.1672-9455.2024.08.014
慢性牙周炎患者唾液中miR-107、miR-106a表达及其诊断价值
Expression and diagnostic value of miR-107 and miR-106a in saliva of patients with chronic periodontitis
摘要
Abstract
Objective To investigate the expression and diagnostic value of miR-107 and miR-106a in saliva of patients with chronic periodontitis.Methods A total of 110 patients with chronic periodontitis diagnosed and treated in the hospital from June 2020 to June 2022 were selected as the observation group.According to the severity of periodontitis,110 patients with chronic periodontitis were divided into mild group(47 cases),moderate group(38 cases)and severe group(25 cases).According to the diagnostic criteria of chronic peri-odontitis in active stage,the patients were divided into active stage group(58 cases)and static stage group(52 cases).At the same time,110 healthy people without oral diseases were selected as the control group.The baseline data and the expression levels of miR-107 and miR-106a in saliva of the observation group and the control group were compared,and the expression levels of miR-107 and miR-106a in saliva of patients with dif-ferent disease severity and different active stages were compared.The receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of miR-107,miR-106a alone and the combined detection of the two indicators for chronic periodontitis.Results There was no significant difference in body mass index be-tween the observation group and the control group(P>0.05).The proportions of gingival bleeding and sub-gingival plaque in the observation group were higher than those in the control group,and the differences were statistically significant(P<0.05).The expression levels of miR-107 and miR-106a in the saliva in the obser-vation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the expression levels of miR-107 and miR-106a in saliva among the mild group,the moderate group and the severe group(P<0.05).The expression levels of miR-107 and miR-106a in the mild group were higher than those in the moderate group and the severe group,and the expression levels of miR-107 and miR-106a in the moderate group were higher than those in the severe group,and the differences were statistically significant(P<0.05).Compared with the static stage group,the expression lev-els of miR-107 and miR-106a in the saliva of the active stage group decreased,and the difference was statisti-cally significant(P<0.05).ROC curve analysis showed that the area under the curve of miR-107 and miR-106a in the diagnosis of chronic periodontitis were 0.771 and 0.742 respectively,which were less than 0.859 of the combined diagnosis of the two indicators(Z=2.200,2.867,P<0.05).Conclusion The expression levels of miR-107 and miR-106a decrease in patients with chronic periodontitis,which can be used as molecular markers for the diagnosis of chronic periodontitis.关键词
慢性牙周炎/微小RNA-107/微小RNA-106a/唾液/诊断价值Key words
chronic periodontitis/micro RNA-107/micro RNA-106a/saliva/diagnostic value分类
医药卫生引用本文复制引用
郭恪,曹屾,邹每伶,王宏瑞,李小慧..慢性牙周炎患者唾液中miR-107、miR-106a表达及其诊断价值[J].检验医学与临床,2024,21(8):1092-1095,1102,5.基金项目
江西省卫生健康委科技计划(20204294). （20204294）
