检验医学与临床2024，Vol.21Issue(8)：1096-1102,7.DOI:10.3969/j.issn.1672-9455.2024.08.015
2型糖尿病患者唾液雌二醇水平及OHIP-14得分与慢性牙周炎严重程度的相关性研究
Correlation of salivary estradiol levels and OHIP-14 scores with severity of chronic periodontitis in patients with type 2 diabetes mellitus
摘要
Abstract
Objective To investigate the correlation of salivary estradiol(E2)levels and oral health impact profile(OHIP-14)scores with the severity of chronic periodontitis(CP)in patients with type 2 diabetes mel-litus(T2DM).Methods A total of 188 T2DM patients admitted to the hospital from October 2022 to March 2023 were selected as the research objects.According to the results of CP examination,98 T2DM patients with CP were selected as the DMCP group,and 90 T2DM patients without CP were selected as the T2DM group,and 80 patients with CP without T2DM were selected as CP group in the Department of Stomatology of our hospital during the same period.The oral hygiene habits,OHIP-14 score,probing depth(PD),attachment loss(AL),bleeding index(BI),saliva E2,white blood cell count(WBC),fasting blood glucose(FBG),glycosylat-ed hemoglobin(HbA1c),triglyceride(TAG),total cholesterol(TC),high density lipoprotein cholesterol and low density lipoprotein cholesterol(LDL-C)level were compared among the three groups.The salivary E2 lev-els and OHIP-14 scores of CP patients with different severity in DMCP group were compared.Spearman cor-relation analysis was used to analyze the correlation of salivary E2 levels and OHIP-14 scores with the severity of CP in T2DM patients.Multivariate Logistic regression was used to analyze the influencing factors of CP in T2DM patients.Receiver operating characteristic(ROC)curve was drawn to analyze the diagnostic value of salivary E2 for CP in T2DM patients.Results The level of E2 in T2DM group was significantly higher than that in DMCP group and CP group(P<0.05).The level of HbA1c in CP group was lower than that in T2DM group and DMCP group,and that in T2DM group was lower than that in DMCP group,and the differences were statistically significant(P<0.05).The levels of FBG,TC and LDL-C in CP group were lower than those in T2DM group and DMCP group,and the differences were statistically significant(P<0.05).WBC in CP group was higher than that in T2DM group,and the difference was statistically significant(P<0.05).The proportion of patients with dental cleaning frequency≥2 times/year in the T2DM group was higher than that in the CP group and the DMCP group,and the differences were statistically significant(P<0.05).The scores of PD,AL,BI and OHIP-14 in CP group were higher than those in T2DM group,and those in T2DM group were lower than those in DMCP group,and the differences were statistically significant(P<0.05).In the DMCP group,there were 21 patients with mild CP,49 patients with moderate CP,and 28 patients with severe CP.In the DMCP group,the salivary E2 level of mild CP patients was higher than that of moderate and severe CP patients,and the salivary E2 level of moderate CP patients was higher than that of severe CP patients,and the differences were statistically significant(P<0.05).The OHIP-14 score of mild CP patients in DMCP group was significantly lower than that of moderate and severe CP patients,and the OHIP-14 score of moder-ate CP patients was significantly lower than that of severe CP patients(P<0.05).Spearman correlation anal-ysis showed that the severity of CP in T2DM patients was negatively correlated with salivary E2 levels(r=-0.268,P<0.05),positively correlated with OHIP-14 scores(r=0.526,P<0.05).Multivariate Logistic re-gression analysis showed that decreased salivary E2 level,increased OHIP-14 score,increased HbA1c level,and increased AL level were risk factors for CP in T2DM patients(P<0.05).ROC curve analysis showed that the area under the curve of salivary E2 for the diagnosis of CP in T2DM patients was 0.875(95%CI:0.827-0.923).Conclusion The low level of E2 in saliva and the high score of OHIP-14 are the risk factors of CP in T2DM patients.The scores of E2 and OHIP-14 in saliva have certain clinical significance in evaluating the risk of CP in T2DM patients.关键词
2型糖尿病/慢性牙周炎/唾液/雌二醇/口腔健康影响程度量表得分/口腔健康Key words
type 2 diabetes mellitus/chronic periodontitis/saliva/estradiol/oral health impact profile score/oral health分类
医药卫生引用本文复制引用
仇彩霞,王祥雨,丁红忠..2型糖尿病患者唾液雌二醇水平及OHIP-14得分与慢性牙周炎严重程度的相关性研究[J].检验医学与临床,2024,21(8):1096-1102,7.基金项目
安徽医科大学附属巢湖医院科研基金项目(2018ykj010). （2018ykj010）
