检验医学与临床2024，Vol.21Issue(8)：1103-1106,4.DOI:10.3969/j.issn.1672-9455.2024.08.016
IL-17 mRNA和PGE2 mRNA在口腔扁平苔藓患者中的表达水平及临床意义
Expression levels and clinical significance of IL-17 mRNA and PGE2 mRNA in patients with oral lichen planus
摘要
Abstract
Objective To investigate the expression and clinical significance of interleukin-17(IL-17)mR-NA and prostaglandin E2(PGE2)mRNA in patients with oral lichen planus(OLP).Methods A total of 35 OLP patients admitted to the Stomatological Hospital,General Hospital of Ningxia Medical University from March 2020 to March 2021 were selected as the experimental group,and 20 patients who underwent impacted tooth extraction in the Stomatological Hospital,General Hospital of Ningxia Medical University during the same period were selected as the control group.The patients in the experimental group were divided into ero-sive OLP group and non-erosive OLP group according to whether the tissue was erosive or not.The expres-sion levels of IL-17 mRNA and PGE2 mRNA in the oral mucosal lesion tissues of the erosive OLP group and the non-erosive OLP group and the control group were detected and compared,and the pain degree of OLP pa-tients was evaluated by visual analogue scale(VAS).The expression levels of IL-17 mRNA and PGE2 mRNA in OLP patients with different degrees of pain were compared.Pearson correlation analysis was used to analyze the correlation between the expression levels of IL-17 mRNA and PGE2 mRNA in patients with OLP.Spearman correlation analysis was used to analyze the correlation between the expression levels of IL-17 mR-NA and PGE2 mRNA and the degree of pain in patients with OLP.Results There were 19 patients in non-e-rosive OLP group and 16 patients in erosive OLP group.The expression levels of IL-17 mRNA and PGE2 mR-NA in erosive OLP group were higher than those in non-erosive OLP group and control group,and those in non-erosive OLP group were higher than control group,and the differences were statistically significant(P<0.05).In the experimental group,there were 5 patients with no pain,6 patients with mild pain,16 patients with moderate pain,and 8 patients with severe pain.The expression levels of IL-17 mRNA and PGE2 mRNA in OLP patients without pain were lower than those in OLP patients with mild,moderate and severe pain,and the differences were statistically significant(P<0.05).Pearson correlation analysis showed that the expres-sion level of IL-17 mRNA correlated positively with the expression level of PGE2 mRNA in OLP patients(r=0.505,P=0.002).Spearman correlation analysis showed that the expression levels of IL-17 mRNA and PGE2 mRNA in OLP patients correlated positively with the degree of pain(r=0.710,0.570,P<0.05).Con-clusion The expression of IL-17 mRNA and PGE2 mRNA is involved in the occurrence and development of OLP,and its expression level correlates positively with the degree of pain in patients with OLP.关键词
口腔扁平苔藓/白细胞介素17/前列腺素2/疼痛程度/信使RNAKey words
oral lichen planus/interleukin-17/prostaglandin 2/pain degree/messenger RNA分类
医药卫生引用本文复制引用
李阳,王珑..IL-17 mRNA和PGE2 mRNA在口腔扁平苔藓患者中的表达水平及临床意义[J].检验医学与临床,2024,21(8):1103-1106,4.基金项目
宁夏回族自治区高等学校科学研究项目(NGY2020039). （NGY2020039）
