摘要
Abstract
Objective To investigate the positive expression and clinical significance of choline kinase α(CHKα),extracellular signal-regulated kinase(ERK)and mitogen-activated protein kinase(MEK)proteins in patients with different grades of glioma.Methods The clinical data of 124 glioma patients admitted to the Department of Neurosurgery,the Fourth Hospital of Changsha from January 2019 to December 2022 were ret-rospectively analyzed.The positive expressions of MEK,ERK and CHKα proteins in patients with glioma of different grades were detected and analyzed.Results The mortality risk of patients with glioma was statisti-cally significant compared with the maximum diameter of different tumors,the age,WHO grade and prognosis of glioma patients with high and low expression of MEK,ERK and CHKα proteins(P<0.05).The positive expression rates of MEK protein in grade Ⅰ,Ⅱ,Ⅲ and Ⅳ gliomas were 9.62%,7.69%,94.08%and 92.04%respectively.The positive expression rates of ERK protein were 9.57%,7.49%,94.52%and 92.18%respec-tively.The positive expression rates of CHKα protein were 9.60%,7.53%,94.71%and 92.23%respectively.There were significant differences in the positive expression rates of MEK,ERK and CHKα proteins between high and low grade patients with glioma(P<0.05).The follow-up results showed that 52 patients died,12 patients were lost to follow-up,and 112 patients were recovered,with a follow-up rate of 90.32%.Conclusion The positive expression of MEK,ERK and CHKα proteins in patients with glioma of different grades are significantly different,and are significantly correlated with the prognosis of the patients,which is of great value for the diagnosis and prognosis of the disease.关键词
胶质瘤/丝裂原激活蛋白激酶/细胞外信号调节激酶/胆碱激酶α/免疫组织化学法Key words
glioma/mitogen-activated protein kinase/extracellular signal-regulated kinase/choline kinase α/immune histochemical method分类
医药卫生
