摘要
Abstract
Objective To investigate the effects of microecological enteral nutrition support on nutritional status,immune function and adverse reactions in patients with radical resection of gastrointestinal malignant tumor(GIM)during postoperative chemotherapy.Methods A total of 110 patients with radical resection of GIM admitted to this hospital from December 2019 to December 2022 were selected as the research objects,they were randomly divided into conventional nutrition group and microecological nutrition group,with 55 ca-ses in each group.The conventional nutrition group was given routine enteral nutritional support,and the mi-croecological nutrition group was given microecological enteral nutritional support.After 24 weeks of inter-vention,the nutritional status[serum albumin(ALB),prealbumin(PA),hemoglobin(Hb),Nutritional Risk Screening 2002(NRS2002)score and body mass index(BMI)],immune function(peripheral blood CD4+T lymphocyte proportion,CD8+T lymphocyte proportion,CD4+/CD8+)and the incidence of adverse reactions(severe nausea and vomiting,bone marrow suppression,oral infection)during the intervention period were compared between the two groups.Results After the intervention,the levels of ALB,PA,Hb,BMI,CD4+T lymphocyte ratio and CD4+/CD8+ in the microecological nutrition group were significantly higher than those in the conventional nutrition group and the NRS2002 score and CD8+T lymphocyte proportion in the micro-ecological nutrition group were significantly lower than those in the conventional nutrition group(P<0.05).During the intervention period,the incidences of severe nausea and vomiting,bone marrow suppression and o-ral infection in the microecological nutrition group were lower than those in the conventional nutrition group,and the differences were statistically significant(P<0.05).Conclusion The application of microecological enteral nutrition support in postoperative radical resection of GIM patients during chemotherapy can signifi-cantly improve the malnutrition status of patients,reduce the occurrence of adverse reactions,improve immune function and help to improve the prognosis of patients.关键词
微生态肠内营养/胃肠道恶性肿瘤/营养状态/免疫功能/不良反应Key words
microecological enteral nutrition/gastrointestinal malignancy/nutritional status/im-mune function/adverse reaction分类
医药卫生
