检验医学与临床2024，Vol.21Issue(8)：1153-1156,4.DOI:10.3969/j.issn.1672-9455.2024.08.027
血药浓度监测在卡马西平中毒老年癫痫患者诊断和治疗中的临床应用
Clinical study of blood concentration monitoring in the diagnosis and treatment of carbamazepine poisoning in elderly patients with epilepsy
摘要
Abstract
Objective To investigate the value of carbamazepine blood concentration monitoring in identif-ying the potential risk of drug poisoning in elderly patients with epilepsy and to provide reference for the diag-nosis and treatment of toxic reactions caused by carbamazepine overdose.Methods To analyze the clinical da-ta,diagnosis and treatment of an elderly patient with epilepsy caused by carbamazepine poisoning.Using"car-bamazepine poisoning"and"carbamazepine overdose"as the search terms,the literature published from the establishment of the database to 2023 was searched in CNKI and PubMed database.Results Overdose toxicity of carbamazepine could still occur under normal usage and dosage.Symptoms could be manifested as extreme-ly high blood drug concentration,impaired liver and kidney function,confusion,disturbance of consciousness,aphasia,recurrent seizures and increased blood pressure.At this time,rehydration and diuresis therapy was ef-fective for elderly patients with epilepsy.Literature search results:a total of 67 Chinese articles and 147 Eng-lish articles were retrieved.Combined with case analysis and literature review,the article summarized the pathogenic factors,clinical diagnosis,treatment and the importance of blood concentration monitoring of car-bamazepine poisoning.Conclusion Elderly patients with epilepsy should be regularly monitored for antiepi-leptic drugs and adjust the dosage in time to avoid the potential risk of toxicity during antiepileptic drug treat-ment.关键词
癫痫/老年人/卡马西平/药物过量/神经系统疾病/卒中/痴呆Key words
epilepsy/the elderly/carbamazepine/drug overdose/nervous system diseases/stroke/dementia分类
医药卫生引用本文复制引用
项瑾,曹国君,陆美娟..血药浓度监测在卡马西平中毒老年癫痫患者诊断和治疗中的临床应用[J].检验医学与临床,2024,21(8):1153-1156,4.基金项目
上海市科学技术委员会"科技创新行动计划"(21Y11900600) （21Y11900600）
上海市"医苑新星"青年医学人才培养资助计划青年医学人才类临床检验项目[沪卫人事(2021)99号]. （2021）
