摘要
Abstract
Objective To analyze the clinical efficacy of Xuebijing injection on patients with severe heat stroke complicated with disseminated intravascular coagulation(DIC)and its influence on prothrombin time(PT),alanine aminotransferase(ALT)and creatinine(Cr)levels.Methods A total of 68 patients with severe heat stroke complicated with DIC admitted to the emergency ward of this hospital from July 2018 to October 2019 were selected as the research objects.They were divided into basic group and Xuebijing group by random number table method,with 34 cases in each group.The basic group was treated with basic antipyretic and anti-spasmodic treatment,and the Xuebijing group was treated with domestic drug Xuebijing injection on the basis treatment of the basic group.The clinical efficacy,coagulation,platelet,renal function,serum enzymes and vas-cular endothelial injury indicators of the two groups were observed.Results The total effective rate of Xuebi-jing group was 97.06%,which was higher than 85.29%of the basic group(P<0.05).There was no statisti-cally significant difference in the PT,activated partial thromboplastin time(APTT),fibrinogen(FIB)level and platelet count(PLT)between the two groups before treatment(P>0.05).After treatment,the levels of FIB level and PLT in the Xuebijing group were higher than those before treatment,and those in the Xuebijing group were higher than those in the basic group,and the PT and APTT were shorter than those before treat-ment,and those in the Xuebijing group were shoeter than those in the basic group(P<0.05).There was no statistically significant differences in the levels of creatine kinase(CK),aspartate aminotransferase(AST),lactate dehydrogenase(LDH)and ALT between the two groups before treatment(P>0.05).The levels of CK,AST,LDH,and ALT in the two groups after treatment were lower than those before treatment,and those in the Xuebijing group were lower than those in the basic group(P<0.05).There was no significant differ-ences in Cr and blood urea nitrogen(BUN)levels between the two groups before treatment(P>0.05).The levels of Cr and BUN in the two groups after treatment were lower than those before treatment,and those in the Xuebijing group were lower than those in the basic group(P<0.05).There was no statistically significant difference in the levels of von Willebrand factor(vWF)and thrombomodulin(TM)between the two groups before treatment(P>0.05).After treatment,the levels of vWF and TM in the two groups were lower than those before treatment,and those in the Xuebijing group were lower than those in the basic treatment group(P<0.05).Conclusion Xuebijing injection can improve the clinical efficacy of severe heat stroke complicated with DIC patients by improving coagulation function,enhancing renal function and reducing endothelial injury.关键词
重症中暑/弥散性血管内凝血/血必净注射液/临床疗效/凝血功能Key words
severe heat stroke/disseminated intravascular coagulation/Xuebijing injection/clinical efficacy/coagulation function分类
医药卫生
