检验医学与临床2024，Vol.21Issue(8)：1176-1181,6.DOI:10.3969/j.issn.1672-9455.2024.08.032
阻塞性睡眠呼吸暂停综合征、肥胖、代谢综合征的病理生理联系及治疗进展
Progress in pathophysiology and treatment of obstructive sleep apnea syndrome,obesity,and metabolic syndrome
摘要
Abstract
The prevalence of overweight and obesity continues to rise globally,and the leading risk factor for obstructive sleep apnea syndrome(OSAS)is obesity,while the number of obese people worldwide has in-creased,the prevalence of OSAS has also increased.OSAS is closely related to obesity.Obesity leads to the pathogenesis of OSAS by promoting airway collapsibility,and OSAS can aggravate obesity through mecha-nisms such as decreased sleep and increased appetite.Obesity is highly susceptible to metabolic syndrome(MS),OSAS has a precipitating effect on MS,and reversing obesity may be the key to break this vicious cy-cle.For OSAS,the main traditional therapy is non-invasive ventilator continuous positive airway pressure therapy.Although this therapy can improve the hypoxia and apnea symptoms of OSAS patients during sleep,it can not improve the metabolic status of patients.At present,the latest advances in the treatment of OSAS include lifestyle intervention such as exercise and diet control,the use of some newly marketed weight loss drugs,traditional Chinese medicine and Chinese acupoints,and the use of designed singing training methods and other methods,as well as brown fat and gene targeted therapy,etc,which are still in the research stage.These new findings may be an effective means to improve the prognosis of OSAS patients with MS and obesi-ty.关键词
阻塞性睡眠呼吸暂停综合征/肥胖/代谢综合征/运动/饮食控制/减肥药物/中医点穴/唱歌训练Key words
obstructive sleep apnea syndrome/obesity/metabolic syndrome/exercise/diet con-trol/weight loss drug/TCM acupoint/singing training分类
医药卫生引用本文复制引用
徐培成,张红,程子敏,陈心雨,马丽..阻塞性睡眠呼吸暂停综合征、肥胖、代谢综合征的病理生理联系及治疗进展[J].检验医学与临床,2024,21(8):1176-1181,6.基金项目
湖北省重点实验室资助项目(OHIC2022G02). （OHIC2022G02）
