兰州大学学报（医学版）2024，Vol.50Issue(2)：80-86,7.DOI:10.13885/j.issn.1000-2812.2024.02.013
浆细胞样树突状细胞在肿瘤及自身免疫性疾病进展中的作用
Dual roles of plasmacytoid dendritic cells in the progression of tumors and autoimmune diseases
摘要
Abstract
Plasmacytoid dendritic cells,a distinctive subset within the dendritic cell family,exhibit a unique immunological profile,in that they are pivotal in the body's immune defense,but interestingly,they can also contribute to disease progression and cause potential harm.Recent years have seen a surge in research explor-ing the intricate biological characteristics,immunological functions and pathogenic mechanisms of plasmacy-toid dendritic cells,especially in the context of tumors and autoimmune disorders.Furthermore,immunothera-pies targeting plasmacytoid dendritic cells have also garnered significant attention.This review aimed to delve deeper into the dualistic nature of plasmacytoid dendritic cells,shedding light on their precise mechanisms and ultimately paving the way for novel treatments in related pathological diseases.关键词
浆细胞样树突状细胞/Ⅰ型干扰素/自身免疫性疾病/肿瘤/免疫疗法Key words
plasmacytoid dendritic cells/type I interferon/autoimmune disease/cancer/immunotherapy分类
医药卫生引用本文复制引用
尹建运,董庆华,苏杭,黄莉,倪倩..浆细胞样树突状细胞在肿瘤及自身免疫性疾病进展中的作用[J].兰州大学学报（医学版）,2024,50(2):80-86,7.基金项目
甘肃省自然科学基金资助项目(22JR5RA986 （）
22JR5RA1006) （）
兰州大学第二医院"萃英科技创新"计划资助项目(CY2020-MS13) （CY2020-MS13）
