兰州大学学报（医学版）2024，Vol.50Issue(2)：87-94,8.DOI:10.13885/j.issn.1000-2812.2024.02.014
肿瘤相关巨噬细胞来源的外泌体在消化系统肿瘤中的作用机制及治疗进展
Mechanism and treatment progress of exosomes derived from tumor-associated macrophages in digestive system tumors
摘要
Abstract
Tumor-associated macrophages play a crucial role in the tumor microenvironment by releasing dif-ferent cytokines to facilitate tumor progression.In addation,these macrophages promote tumor proliferation,invasion,metastasis,angiogenesis,and enhance drug resistance by transmitting exosomes containing proteins,lipids and various types of ribonucleic acid to tumor cells.This review examined the regulatory effects and molecular mechanisms of tumor-associated macrophage-derived exosomes on digestive system tumors.Addi-tionally,it presents strategies to prevent and treat digestive system tumors based on exosome research,offer-ing new insights into the development of clinical drugs.关键词
肿瘤相关巨噬细胞/肿瘤微环境/外泌体/消化系统肿瘤/免疫治疗Key words
tumor-associated macrophages/tumor microenvironment/exosomes/digestive system tumor/im-munotherapy分类
医药卫生引用本文复制引用
刘小央,闵晓翠,王芙蓉..肿瘤相关巨噬细胞来源的外泌体在消化系统肿瘤中的作用机制及治疗进展[J].兰州大学学报（医学版）,2024,50(2):87-94,8.基金项目
甘肃省自然科学基金资助项目(22JR11RA054) （22JR11RA054）
