临床输血与检验2024，Vol.26Issue(2)：239-243,5.DOI:10.3969/j.issn.1671-2587.2024.02.013
江西南昌地区16例B(A)表型个体的血清学特征和基因型分析
Serological Characteristics and Genotypes of 16 Cases with B(A)Phenotype in Nanchang Prefecture of Jiangxi Province
摘要
Abstract
Objective To study the serological characteristics and genotype of B(A)phenotype in Nanchang prefecture of Jiangxi province.Methods The phenotype of AwB or AB was collected.ABO blood typing was performed by serological method on 16 highly suspected B(A)blood samples with ABO discrepancies,and family samples from 1 proband.All samples were re-examined by serological method and were subjected to sequence analysis of exons 6 and 7.Absorption-elution tests were performed to detect the reaction of B(A)samples to human anti-A.Results All 16 samples were typed as AwB and weak anti-A was found in serum.Ten samples were genotyped as ABO*BA.04 and 6 samples were ABO*BA.02.Of the 6 samples in absorption-elution tests,4 samples with ABO*BA.04 genotype were negative,and 2 samples with ABO*BA.02 genotype showed weakly positive with human anti-A.Pedigree study showed that the ABO*BA.04 allele inherited from the father and was passed on to the son.Conclusions The serological characteristics of B(A)phenotype are similar to AwB with ABO discrepancies,so it is recommended to identify them by molecular biological methods.Different types of B(A)individuals have different A antigens on cells and reaction ability to human anti-A.关键词
血型/B(A)表型/血清学特征/基因型Key words
Blood group/B(A)phenotype/Serological characteristic/Genotype分类
医药卫生引用本文复制引用
徐晶,舒轶,杜忻,徐晓琴..江西南昌地区16例B(A)表型个体的血清学特征和基因型分析[J].临床输血与检验,2024,26(2):239-243,5.基金项目
本课题受江西省卫生厅科技计划项目(No.SKJP220200224)资助 （No.SKJP220200224）
