临床输血与检验2024，Vol.26Issue(2)：282-288,7.DOI:10.3969/j.issn.1671-2587.2024.02.019
血红蛋白类氧载体的研究进展及应用前景
Research Progress and Application Prospect of Hemoglobin-based Oxygen Carriers
摘要
Abstract
Red blood cell transfusion has been widely used in trauma treatment,surgery,anemia treatment,war wound emergency treatment and other aspects,but there are still problems such as shortage of blood resources,short storage period,cross-matching before transfusion,and possible transmission of pathogens through blood.Hemoglobin-based oxygen carriers(HBOCs)are a class of soluble nano-oxygen carriers prepared by chemical modification of matrix-free hemoglobin,which can replace red blood cells to transport oxygen to organs and tissues in the body.HBOCs have the characteristics of no blood group and virus transmission risk,long storage,and instant use,so they are also known as red blood cell substitutes.This paper aims to review the research progress of HBOCs,and explore their application prospects in organ preservation,cerebral ischemia,tumor treatment and other treatments in addition to the replacement of red blood cell transfusion.关键词
红细胞代用品/血红蛋白氧载体/创伤/贫血/器官保存/脑缺血/肿瘤Key words
Red Blood Cell Substitutes/Hemoglobin oxygen carrier/Trauma/Anemia/Organ preservation/Cerebral ischemia/Tumor分类
临床医学引用本文复制引用
李洋,杨明峰,王莹,张坚,刘嘉馨,孙保亮..血红蛋白类氧载体的研究进展及应用前景[J].临床输血与检验,2024,26(2):282-288,7.基金项目
本课题受山东省自然科学基金重大基础研究项目(No.ZR2019ZD32)资助 （No.ZR2019ZD32）
