内科理论与实践2024，Vol.19Issue(1)：31-36,6.DOI:10.16138/j.1673-6087.2024.01.06
对耶氏肺孢子菌肺炎患者进行复方磺胺甲(噁)唑治疗药物监测的重要性研究
Importance of drug monitoring for compound sulfamethoxazole therapy in patients with Pneumocystis jiroveci pneumonia
方洁 1陈超 1周敏2
作者信息
- 1. 上海交通大学医学院附属瑞金医院药剂科 上海交通大学医学院呼吸病研究所,上海 200025
- 2. 上海交通大学医学院附属瑞金医院呼吸与危重症医学科 上海交通大学医学院呼吸病研究所,上海 200025
- 折叠
摘要
Abstract
Pneumocystis jiroveci pneumonia(PJP)is one of the more common and serious opportunistic infections in patients with human immunodeficiency virus(HIV).With the use of immunosuppressants and chemotherapy drugs,most PJP cases reported in China are non-HIV immunosuppressed patients.Compound sulfamethoxazole(SMZco)is the first-line drug for the treatment of PJP,and there are wide individual differences in its pharmacokinetics.Through citing a PJP case treated with SMZco under drug monitoring,a systematic review was conducted from the aspects of SMZco pharmacokinetics,dose-related adverse reactions,and optimal therapeutic dose research.It aims to demonstrate the importance of drug monitoring for sulfamethoxazole therapy,which ensures the drug reaches effective therapeutic concentrations and the occurrence of its'adverse reactions was reduced.关键词
耶氏肺孢子菌肺炎/复方磺胺甲(噁)唑/治疗药物监测Key words
Pneumocystis jiroveci pneumonia/Compound sulfamethoxazole/Therapeutic drug monitoring分类
医药卫生引用本文复制引用
方洁,陈超,周敏..对耶氏肺孢子菌肺炎患者进行复方磺胺甲(噁)唑治疗药物监测的重要性研究[J].内科理论与实践,2024,19(1):31-36,6.
