农药学学报2024，Vol.26Issue(2)：211-223,13.DOI:10.16801/j.issn.1008-7303.2023.0106
几丁质脱乙酰酶的生物学功能、三维结构及其抑制剂的研究进展
Research progress on biological function,three-dimensional structure and inhibitors of chitin deacetylase:a review
摘要
Abstract
The development of new targets has become a top priority in pesticide research and development due to the problems of limited targets and drug resistance in agrochemicals.Chitin is a major component of insect epidermis and fungal cell wall,and has important biological functions.Chitin deacetylase(CDA)can deacetylate chitin to chitosan,which not only affects the formation of insect body wall and fungal cell wall,but also regulates the growth and development of insects or determines the pathogenicity of fungi.More and more studies have shown that CDA is expected to be a candidate target for the development of new pesticides.Therefore,the research progress of CDA as a potential target for crop protection,especially the biochemical functions,crystal structures,enzyme-substrate binding modes,and reported inhibitors of CDA from different sources in recent years were summarized in this review.The aim is to provide guidance for the screening of inhibitors targeting CDA and the development of novel pesticides.关键词
几丁质脱乙酰酶/生物功能/潜在应用价值/晶体结构/抑制剂/研究进展Key words
chitin deacetylase/biological function/potential applications/crystal structure/inhibitors/research advances分类
农业科技引用本文复制引用
徐欢,何祺,崔佳琳,靳彬艳,路星星,张晓鸣,凌云,张莉..几丁质脱乙酰酶的生物学功能、三维结构及其抑制剂的研究进展[J].农药学学报,2024,26(2):211-223,13.基金项目
国家自然科学基金(22177132) （22177132）
国家重点研发计划(2022YFD1700204).Supported by the National Natural Science Foundation of China(No.22177132)and the National Key R&D Program of China(No.2022YFD1700204). （2022YFD1700204）
