农药学学报2024，Vol.26Issue(2)：224-233,10.DOI:10.16801/j.issn.1008-7303.2023.0103
昆虫Ⅱ家族几丁质酶的生理功能、结构特征及其抑制剂研究进展
Research progress on physiological functions,structures and inhibitors of insect group Ⅱ chitinase
摘要
Abstract
Insect chitinases can degrade chitin in the insect body wall and peritrophic membrane,thus playing a crucial role in insect molting and other life activities.Among the key enzymes involved in the chitin degradation system of insects,group Ⅱ chitinase(ChtⅡ)is a specific enzyme with multiple domains and complex functions.Silencing of the gene encoding ChtⅡ in insects can lead to molting failure and increased mortality.The analysis of the biochemical properties and crystal structure of ChtⅡ indicates its"pioneering and tackled"role in the chitin degradation system.Thus,ChtⅡ is expected to be a new target for insecticides.This paper reviews recent progress on the physiological function,structural characteristics,and inhibitors of ChtⅡ,aiming to provide insights for the creation of green pesticides based on insect chitinases.关键词
杀虫剂靶标/Ⅱ家族几丁质酶(ChtⅡ)/生理功能/晶体结构/抑制剂/生物活性Key words
insecticide target/group Ⅱ chitinase(ChtⅡ)/physiological function/crystal structure/inhibitor/bioactivity分类
化学化工引用本文复制引用
谢慧杰,丁艺,胡雪,杨青,刘田..昆虫Ⅱ家族几丁质酶的生理功能、结构特征及其抑制剂研究进展[J].农药学学报,2024,26(2):224-233,10.基金项目
国家重点研发计划(2022YFD1700200) （2022YFD1700200）
国家自然科学基金(32170502) （32170502）
辽宁省自然科学基金(2022-KF-15-02).Supported by the National Key R&D Program of China(No.2022YFD1700200),the National Natural Science Foundation of China(No.32170502),and the Project of Natural Science Foundation of Liaoning Province(No.2022-KF-15-02). （2022-KF-15-02）
