农药学学报2024，Vol.26Issue(2)：234-245,12.DOI:10.16801/j.issn.1008-7303.2024.0034
昆虫鱼尼丁受体结构功能及抗性机制研究进展
Advances in structural and functional studies of the insect ryanodine receptor and the related resistance mechanisms
摘要
Abstract
Diamide insecticides are used to control a variety of destructive agricultural Lepidopteran and Coleopteran pests.They possess a novel mechanism of action and are safe for nontarget organisms;thus,they have become among the best-selling insecticides in the world.Mutations recently discovered in resistant insect populations significantly reduce their efficacy,causing enormous economic losses to agricultural production in various countries.The molecular target of diamide insecticides,the ryanodine receptor(RyR),has been widely studied as a new hot target and has received much attention in recent years.The latest findings on the structure and function of insect RyRs,including 1)the binding site and mode of action of diamide insecticides,2)the impacts of resistance mutations on the structure and function of RyRs,3)potential new target sites on RyRs other than the diamide insecticides binding site,and 4)structural differences of the classic and new target sites between the target and nontarget organisms,were summarized in the review.Finally,how the progress in RyR structural biology might facilitate the design and development of a new generation of green pesticides was also discussed.关键词
鱼尼丁受体/双酰胺类杀虫剂/作用机制/抗性Key words
ryanodine receptor/diamide insecticide/mode of action/resistance分类
化学化工引用本文复制引用
马舒玥,HADIATULLAH Hadiatullah,王纹岚,尉迟之光..昆虫鱼尼丁受体结构功能及抗性机制研究进展[J].农药学学报,2024,26(2):234-245,12.基金项目
科技部重点研发项目(2022YFE0108400) （2022YFE0108400）
国家自然科学基金(32372580) （32372580）
物质绿色创造与制造海河实验室资助项目.Supported by National Key Research and Development Program of China(No.2022YFE0108400),the National Natural Science Foundation of China(No.32372580)and the Haihe Laboratory of Sustainable Chemical Transformations. （No.2022YFE0108400）
