农药学学报2024，Vol.26Issue(2)：266-277,12.DOI:10.16801/j.issn.1008-7303.2024.0030
对羟苯基丙酮酸双加氧酶的研究进展
Review of 4-hydroxyphenylpyruvate dioxygenase
摘要
Abstract
Innovating the action targets and mechanism of pesticides represents one of the critical scientific challenges necessitating resolution within the realm of pesticide science research.4-Hydroxyphenylpyruvate dioxygenase(HPPD)is an essential enzyme in the tyrosine metabolism pathway,with varying metabolic roles across different organisms.Exploratory research indicates that HPPD plays a substantial role in pharmaceuticals and herbicide applications.Recent studies unveiled the potential HPPD inhibitors in antifungal agents and mosquito repellents,emphasizing its versatile and promising applications.Consequently,this review summarizes HPPD's physiological roles in diverse organisms,detailing its metabolic functions in humans,blood-feeding arthropods,plants,and fungi.It provides a comparative analysis of HPPD crystal structures from different species and discusses its applications in medicine and pesticides(herbicides,insecticides,and fungicides)along with future research perspective.关键词
对羟苯基丙酮酸双加氧酶(HPPD)/农药靶标/绿色农药/研究进展Key words
4-hydroxyphenylpyruvate dioxygenase(HPPD)/pesticide targets/green pesticide/research progress分类
化学化工引用本文复制引用
林若煊,邹用科,柳国蓉,董进,于欣禾,林红艳,杨光富..对羟苯基丙酮酸双加氧酶的研究进展[J].农药学学报,2024,26(2):266-277,12.基金项目
国家自然科学基金项目(22377031) （22377031）
武汉市知识创新专项(2022013301015174) （2022013301015174）
湖北省重点研发计划(022BBA001).Supported by the National Natural Science Foundation of China(No.22377031),Knowledge Innovation Program of Wuhan-Basic Research(No.2022013301015174),the Key Research and Development Program of Hubei Province(No.2022BBA001). （022BBA001）
