农药学学报2024，Vol.26Issue(2)：290-300,11.DOI:10.16801/j.issn.1008-7303.2024.0020
漆酶:一种新型靶标在农业杀菌剂开发中的潜在应用
Laccase:a novel target with potential applications in development of agricultural fungicides
摘要
Abstract
Consequently,identifying new green fungicides has become critical.Currently,the molecular design of fungicides depends on known targets,but the repeated use of fungicides targeting a single pathway undoubtedly increases the risk of cross-resistance in harmful organisms.Therefore,the development of fungicides with novel mechanisms of action based on new targets can effectively solve the problem of pathogenic bacteria resistance to existing fungicides.Laccase is a key enzyme in the biosynthesis pathway of dihydroxynaphthalene melanin.Its absence can affect fungal growth and development and pathogenic infestation,and may be investigated as a potential target for pesticide fungicides.This paper introduces the structure and functionality of laccase,spotlighting recent advances in the study of compounds with laccase inhibitory activity as promising agents.With the hope of providing guidance for the discovery of more novel laccase inhibitors as fungicides.关键词
漆酶/杀菌剂靶标/漆酶抑制剂/抑菌活性/氨基硫脲衍生物Key words
laccase/fungicide target/laccase inhibitors/antifungal activity/thiosemicarbazide derivatives分类
化学化工引用本文复制引用
路星星,孙腾达,徐欢,杨新玲,刘西莉,张晓鸣,凌云..漆酶:一种新型靶标在农业杀菌剂开发中的潜在应用[J].农药学学报,2024,26(2):290-300,11.基金项目
国家自然科学基金项目(22077137,21472236).Supported by National Natural Science Foundation of China(No.22077137 and No.21472236). （22077137,21472236）
