肿瘤预防与治疗2024，Vol.37Issue(4)：328-334,7.DOI:10.3969/j.issn.1674-0904.2024.04.008
食管癌合并HIV感染/AIDS患者临床特征及淋巴结转移的危险因素分析
Clinical Characteristics of Patients with Esophageal Carcinoma Combined with HIV Infection/AIDS and Their Risk Factors for Lymph Node Metas-tasis
摘要
Abstract
Objective:To analyze the clinical characteristics of patients with esophageal carcinoma combined with human immunodeficiency virus(HIV)infection/acquired immune deficiency syndrome(AIDS)and their risk factors of lymph node metastasis.Methods:This study retrospectively analyzed the clinical data of patients with esophageal cancer combined with HIV infection/AIDS who underwent surgery at the department of thoracic surgery in Public Health Clinical Center of Chengdu from November 2020 to December 2022,summarized the clinical characteristics of esophageal carcinoma in this population,and analyzed the factors affecting lymph node metastasis.Results:A total of 33 patients were included in this study,with a mean age of(60.39±10.09)years.93.94％(31/33)of the patients were male,6.06％(2/33)were fe-male,and 75.75％(25/33)had a history of alcohol consumption.54.54％(18/33)of the patients with HIV infection/AIDS had lymph node metastasis,and the rate of cleared lymph node metastasis was 10.30％(65/631).Univariate analysis revealed that the maximum diameter of the tumour,clinical stage,depth of infiltration,lymphovascular tumor embolus,CD4+T lymphocyte count,HIV viral load and preoperative serum albumin were associated with the occurrence of lymph node metastasis(P＜0.05).Multivariate logistic regression analysis showed that CD4+T lymphocyte count＜200 cells/μL,viral load ≥20 copies/mL,and preoperative serum albumin＜35 g/L were independent risk factors for lymph node metastasis in esophageal cancer patients with HIV infection/AIDS(P＜0.05).Conclusion:Esophageal carcinoma patients with HIV in-fection/AIDS are prone to lymph node metastasis when they have high viral loads,severe immune compromise and low nutri-tional status.Control of viral load,improvement of patients'immunity and malnutrition,and comprehensive cancer treatment are particularly critical in the treatment cycle of the population.关键词
食管癌/人类免疫缺陷病毒/艾滋病/淋巴结转移/危险因素Key words
Esophageal carcinoma/Human immunodeficiency virus/AIDS/Lymph node metastasis/Risk factors分类
医药卫生引用本文复制引用
王宁,李刚,李丹,龚胜,袁晔,周君,陈朝琼,姚晓军..食管癌合并HIV感染/AIDS患者临床特征及淋巴结转移的危险因素分析[J].肿瘤预防与治疗,2024,37(4):328-334,7.基金项目
This study was supported by grants from Health Commission of Chengdu(No.2021089).成都市医学科研课题(编号:2021089) （No.2021089）
