鼻咽癌患者生命质量评价及其影响因素分析OACSTPCD

Objective To assess the quality of life in patients with nasopharyngeal carcinoma and to investigate its possible mechanism.Methods A total of 121 patients with nasopharyngeal cancer were included in the study.The qual-ity of life instrument for nasopharyngeal cancer patients QLICP-NA(V2.0)was used to evaluate their quality of life from the following five domains:physical functioning,psychological functioning,social functioning,common symptoms and ad-verse reactions,and specific modules.General demographic data(including 11 factors such as gender,age,and marital status,etc.)were collected,and multiple linear regression analysis was conducted to determine the effects of these vari-ables on the patients'quality of life.Additionally,15 clinical objective indicators[albumin(Alb),globulin(G),alanine aminotransferase(ALT),total bilirubin(TB),total bile acids(TBA),alkaline phosphatase(ALP),γ-glutamyltransfer-ase(GGT),urea(BUN),Cratinine(Cr),lactate dehydrogenase(LDH),aspartate aminotransferase(AST),white blood cell count(WBC),red blood cell count(RBC),hemoglobin(Hb),and platelets(PLT)]were collected and analyzed to determine their correlation and typical correlation with the patients'quality of life.Results The physical functioning score of nasopharyngeal carcinoma patients was 61.03±15.63,the psychological functioning score was 60.95±15.35,the social functioning score was 59.17±14.16,the common symptom and adverse reaction score was 71.49±19.40,the specific module score was 75.62±14.87,and the total score of the scale was 66.10±11.58,respectively.Clinical stag-ing was an independent influencing factor for physical functioning,psychological functioning,social functioning scores,and the total scale score;family economic status was an independent influencing factor for psychological functioning and so-cial functioning scores;age was an independent influencing factor for the total scale score(all P<0.05).The physical functioning score was positively correlated with Alb,TB,Cr,RBC,and Hb;the psychological functioning score was posi-tively correlated with ALT,AST,and Hb;the social functioning score was positively correlated with ALT,RBC,and Hb;the common symptom and adverse reaction score was positively correlated with Alb,Cr,RBC,and Hb(all P<0.05).The specific module score was positively correlated with RBC and Hb,and was negatively correlated with ALT,LDH,and AST(all P<0.05).Among the automatically extracted five pairs of typical variables,only the first pair had a statistically signif-icant difference(canonical correlation coefficient 0.561,contribution rate 41.26%,P<0.05).The standardized canoni-cal coefficients for ALT,AST,and Hb were relatively large(0.465,-0.443,-0.736)in the clinical objective indica-tors,and the standardized canonical coefficient for physical functioning was large(-0.878)in various domains of quality of life.The first pair of typical variables from the clinical objective indicator variables could explain 42.8%of the variation in the corresponding clinical objective indicator group and 13.5%of the variation in the opposing five-domain score vari-able group.The first pair of typical variables from the five-domain score variable group could explain 12.2%of the varia-tion in the corresponding five-domain score variable group and 3.8%of the variation in the opposing clinical objective indi-cator variable group.Conclusions The domain scores of quality of life in nasopharyngeal carcinoma patients ranked from high to low are specific module,common symptoms and adverse reactions,physical functioning,psychological func-tioning,and social functioning.The influencing factors included clinical staging,family economic status,age,and certain clinical objective indicators.