山东医药2024，Vol.64Issue(11)：21-26,6.DOI:10.3969/j.issn.1002-266X.2024.11.005
鼻咽癌患者生命质量评价及其影响因素分析
Evaluation of quality of life of nasopharyngeal carcinoma patients and analysis of influencing factors
摘要
Abstract
Objective To assess the quality of life in patients with nasopharyngeal carcinoma and to investigate its possible mechanism.Methods A total of 121 patients with nasopharyngeal cancer were included in the study.The qual-ity of life instrument for nasopharyngeal cancer patients QLICP-NA(V2.0)was used to evaluate their quality of life from the following five domains:physical functioning,psychological functioning,social functioning,common symptoms and ad-verse reactions,and specific modules.General demographic data(including 11 factors such as gender,age,and marital status,etc.)were collected,and multiple linear regression analysis was conducted to determine the effects of these vari-ables on the patients'quality of life.Additionally,15 clinical objective indicators[albumin(Alb),globulin(G),alanine aminotransferase(ALT),total bilirubin(TB),total bile acids(TBA),alkaline phosphatase(ALP),γ-glutamyltransfer-ase(GGT),urea(BUN),Cratinine(Cr),lactate dehydrogenase(LDH),aspartate aminotransferase(AST),white blood cell count(WBC),red blood cell count(RBC),hemoglobin(Hb),and platelets(PLT)]were collected and analyzed to determine their correlation and typical correlation with the patients'quality of life.Results The physical functioning score of nasopharyngeal carcinoma patients was 61.03±15.63,the psychological functioning score was 60.95±15.35,the social functioning score was 59.17±14.16,the common symptom and adverse reaction score was 71.49±19.40,the specific module score was 75.62±14.87,and the total score of the scale was 66.10±11.58,respectively.Clinical stag-ing was an independent influencing factor for physical functioning,psychological functioning,social functioning scores,and the total scale score;family economic status was an independent influencing factor for psychological functioning and so-cial functioning scores;age was an independent influencing factor for the total scale score(all P<0.05).The physical functioning score was positively correlated with Alb,TB,Cr,RBC,and Hb;the psychological functioning score was posi-tively correlated with ALT,AST,and Hb;the social functioning score was positively correlated with ALT,RBC,and Hb;the common symptom and adverse reaction score was positively correlated with Alb,Cr,RBC,and Hb(all P<0.05).The specific module score was positively correlated with RBC and Hb,and was negatively correlated with ALT,LDH,and AST(all P<0.05).Among the automatically extracted five pairs of typical variables,only the first pair had a statistically signif-icant difference(canonical correlation coefficient 0.561,contribution rate 41.26%,P<0.05).The standardized canoni-cal coefficients for ALT,AST,and Hb were relatively large(0.465,-0.443,-0.736)in the clinical objective indica-tors,and the standardized canonical coefficient for physical functioning was large(-0.878)in various domains of quality of life.The first pair of typical variables from the clinical objective indicator variables could explain 42.8%of the variation in the corresponding clinical objective indicator group and 13.5%of the variation in the opposing five-domain score vari-able group.The first pair of typical variables from the five-domain score variable group could explain 12.2%of the varia-tion in the corresponding five-domain score variable group and 3.8%of the variation in the opposing clinical objective indi-cator variable group.Conclusions The domain scores of quality of life in nasopharyngeal carcinoma patients ranked from high to low are specific module,common symptoms and adverse reactions,physical functioning,psychological func-tioning,and social functioning.The influencing factors included clinical staging,family economic status,age,and certain clinical objective indicators.关键词
生命质量/鼻咽癌/TNM分期Key words
quality of life/nasopharyngeal carcinoma/TNM staging分类
医药卫生引用本文复制引用
张娅妮,陈添良,罗添馨,冯晓红,万崇华,吴家园,胡利人,杜进林,杨铮..鼻咽癌患者生命质量评价及其影响因素分析[J].山东医药,2024,64(11):21-26,6.基金项目
广东省普通高校重点科研平台和科研项目(2018KTSCX074). （2018KTSCX074）
