神经病学与神经康复学杂志2023，Vol.19Issue(4)：105-111,7.DOI:10.12022/jnnr.2023-0204
基于孟德尔随机化研究探讨炎症性肠病与癫痫的因果关系
Causal relationship between inflammatory bowel disease and epilepsy:evidence from genetic correlation and Mendelian randomization study
黄敏 1谢济清1
作者信息
- 1. 广州市社会福利院,广东广州 510700
- 折叠
摘要
Abstract
Objective:To investigate the causal role with Inflammatory bowel disease(IBD)and epilepsy through Mendelian randomization(MR)approach.
Methods:Genetic association data for IBD were collected through the International IBD Genetics Consortium(25 042 cases and 34 915 controls)and genetic association data for epilepsy were from International League Against Epilepsy Consortium(15 212 cases and 29677 controls)MR analyses were performed using the summary level data for epilepsy extracted above genetic association data to obtain the causal estimates.The inverse variance weighting(IVW)method of the random effects model was the main analysis method,supplemented by the WME and MR-Egger methods,the OR value was used to present the results.
Results:A total of 70 single nucleotide polymorphism(SNP)closely associated with epilepsy as instrumental variables from the pooled database were obtained,and the IVW results(OR=0.98,95％CI:0.96～0.99,P=0.01)indicated that genes predicted IBD has a causal relationship with epilepsy.MR-Egger regression results(P=0.77)and PRESSO test indicated that there was no horizontal pleiotropy of genes in our findings.
Conclusion:There is a causal association between epilepsy and IBD,and the variant of rs212402 may be the key to IBD affecting epilepsy.关键词
炎症性肠病/癫痫/孟德尔随机化/因果推断Key words
Inflammatory bowel disease/Epilepsy/Mendelian randomization/Causal inference引用本文复制引用
黄敏,谢济清..基于孟德尔随机化研究探讨炎症性肠病与癫痫的因果关系[J].神经病学与神经康复学杂志,2023,19(4):105-111,7.
