生物技术通报2024，Vol.40Issue(4)：1-11,11.DOI:10.13560/j.cnki.biotech.bull.1985.2023-1095
泛素化修饰关键酶在植物抗逆反应中的功能研究进展
Research Progress in the Functions of Key Enzymes of Ubiquitination Modification in Plant Stress Responses
摘要
Abstract
Ubiquitination is one of post-translational modifications of plant proteins,which is involved in the regulation of plant growth,development and various stress responses by selective degradation of proteins.The reaction of ubiquitination modification is carried out by the synergistic action of three key enzymes.Ubiquitin molecules are activated by linking to thiol ester bonds of ubiquitin-activating enzymes,and the activated ubiquitin molecules form a complex with ubiquitin-conjugating enzymes,and finally bind to the target protein under the action of ubiquitin-ligase enzymes.With the development of proteomics sequencing technology,the research on ubiquitination modification has become more widespread and deeper.A large number of ubiquitination modified proteins and their modification sites have been identified,which is conducive to further understanding the regulatory mechanism of proteins and further analyzing the function of proteins.In this paper,we mainly introduced the reaction process of the ubiquitin-proteasome system,the structure,quantity and classification of key enzymes of ubiquitination modification,and focused on the functions of ubiquitin-activating enzymes,ubiquitin-binding enzymes and ubiquitin-ligases in plant response to abiotic and biotic stresses.Concurrently,we summarized the issues in studying functions of the key enzymes in plant ubiquitination modification,and discussed the crosstalk between ubiquitination and other modifications,which is of great significance for further research on ubiquitination modification in the field of plant responses to various environmental stresses.关键词
泛素化修饰/泛素激活酶/泛素结合酶/泛素连接酶/非生物胁迫/生物胁迫Key words
ubiquitination modification/ubiquitin-activating enzyme/ubiquitin-conjugating enzyme/ubiquitin-ligase enzyme/abiotic stress/biotic stress引用本文复制引用
郭慧妍,董雪,安梦楠,夏子豪,吴元华..泛素化修饰关键酶在植物抗逆反应中的功能研究进展[J].生物技术通报,2024,40(4):1-11,11.基金项目
国家自然科学基金项目(31801702) （31801702）
