现代科学仪器2024，Vol.41Issue(2)：10-15,6.
HPLC-MS/MS测定保健食品中6种大麻素
Determination of six Cannabinoid in health food by HPLC-MS/MS
摘要
Abstract
Objective:Qualitative and quantitative analysis of six cannabinoids in health food using high-performance liquid chromatography tandem triple quadrupole mass spectrometry(HPLC-MS/MS).Methods:HLB solid phase extraction column purification,using XBridge C18 chromatography column,with acetonitrile solution as the organic phase and 10 mmol·L-1 ammonium acetate aqueous solution as the aqueous phase.Two ions modes were scanned simultaneously and isotope internal standard quantification was performed.Results:The measured Cannabinoids between 1-100μg·L-1 concentration range shows a good linear relationship,and the correlation coefficients(r2)is greater than 0.999.The detection limit and quantification limit of the method are 5 μg·kg-1 and 10 μg·kg-1.The method has good stability and high sensitivity,and is suitable for qualitative and quantitative analysis of six Cannabinoid in common health products.Conclusion:This study successfully established established a qualitative and quantitative analysis of six cannabinoids in health food,providing technical support for quality evaluation,safety supervision,and risk prevention of health food.关键词
大麻素/保健食品/高效液相色谱-串联质谱Key words
Cannabinoids/Health food/High performance liquid chromatography-tandem mass spectrometry引用本文复制引用
侯巧红,邹明强,金明华,胡婷婷,张勋,赵宇,齐鹤鸣,李孟璇,步献功,董昕,李燕鹭,宋清莲..HPLC-MS/MS测定保健食品中6种大麻素[J].现代科学仪器,2024,41(2):10-15,6.基金项目
海关总署科研项目2020HK182,海南省重点研发计划项目ZDYF2021SHFZ069,吉林省科技发展计划项目(重点研发项目)20210203045SF,中国海关科学技术研究中心研课题2023HX07 （重点研发项目）
