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逆转冠状动脉粥样硬化的成像模式及治疗策略OACSTPCD

Imaging modalities and treatment strategies for reversing coronary atherosclerosis

中文摘要英文摘要

冠状动脉粥样硬化的演变是个连续的过程,然而,斑块形成过程的时间演变(如炎症、脂质积累、钙化或斑块破裂、愈合)很少在人体内被连续监测.血管内斑块发展过程的可视化可以帮助指导患者管理和了解治疗的效果.随着成像技术的不断发展,斑块的组成成分、坏死核心体积大小、纤维帽厚度和正性重塑等高危斑块特征可预测心血管事件的风险,提示斑块增大或者消退.但是斑块性质不同,斑块消退的程度也大相径庭.本文就评估斑块消退的成像模式以及可能诱发冠状动脉粥样硬化斑块消退的治疗策略作一综述.

The evolution of coronary atherosclerosis is a continuous process.However,the temporal evolution of plaque formation processes,such as inflammation,lipid accumulation,calcification,or plaque rupture and healing,has rarely been continuously monitored in the human body.Visualization of the progression of plaque in the vessel can help to guide the patient management and understand the effect of treatment.With the continuous development of imaging technology,high-risk plaque characteristics such as plaque composition,necrotic core volume,fibrous cap thickness and positive remodeling can predict the risk of cardiovascular events,and also suggest plaque increase or regression.However,the degree of plaque regression varies greatly with the nature of the plaque.This article reviews the imaging modalities used to evaluate plaque regression and therapeutic strategies that may induce regression of coronary atherosclerotic plaques.

马超群;刘小伟;唐礼江

310053 杭州,浙江中医药大学第二临床医学院310013 杭州,浙江医院

冠状动脉粥样硬化缺血性心脏病斑块逆转斑块成像

AtherosclerosisIschemic heart diseaseReversal of plaqueImaging of plaque

《心脑血管病防治》 2024 (002)

41-45 / 5

浙江省医药卫生重大科技计划项目(2015128660);浙江省中医药科技计划(2023ZL217)

10.3969/j.issn.1009-816x.2024.02.009

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