新医学2024，Vol.55Issue(4)：265-269,5.DOI:10.3969/j.issn.0253-9802.2024.04.005
网膜素-1在糖尿病肾病中的保护作用机制研究进展
Research progress in the protection mechanism of omentin-1 in diabetic nephropathy
摘要
Abstract
Diabetic nephropathy is one of microvascular complications of diabetic nephropathy(DN)and the main cause of end-stage renal disease.Inflammation,oxidative stress,endothelial and podocyte dysfunction and metabolic abnormalities play critical roles in the pathogenesis of DN.Increasing evidence has demonstrated that omentin-1 exerts a variety of biological effects and can play a role in kidney protection.In DN patients,omentin-1 levels are generally reduced,which impairs anti-inflammation,anti-oxidative stress,endothelial cell and podocyte function and insulin resistance,and further aggravates the progression of nephropathy.In this article,the protection mechanism of omentin-1 in DN was illustrated from its role in the regulation of inflammation,oxidative stress,improvement of endothelial cell and podocyte function,and improvement of insulin resistance,aiming to provide novel ideas for the diagnosis and treatment of DN.关键词
网膜素-1/糖尿病肾病/作用机制/氧化应激/胰岛素抵抗Key words
Omentin-1/Diabetic nephropathy/Mechanism/Oxidative stress/Insulin resistance引用本文复制引用
刘阳春,何依草,周大舜,张海松..网膜素-1在糖尿病肾病中的保护作用机制研究进展[J].新医学,2024,55(4):265-269,5.基金项目
河北省引进留学人员资助项目(C202110357) （C202110357）
