医药导报2024，Vol.43Issue(5)：696-699,4.DOI:10.3870/j.issn.1004-0781.2024.05.004
电感耦合等离子体发射光谱法测定药用卤化丁基橡胶塞表面硅油量
Determination of Polydimethylsiloxane on the Surface of Pharmaceutical Halogenated Butyl Rubber Stoppers by Inductively Coupled Plasma Optical Emission Spectrometry
陈晓莉 1付蒙 1王经纬 2胡敏 1赵霞3
作者信息
- 1. 湖北省药品监督检验研究院,湖北省药品质量检测与控制工程技术研究中心,国家药品监督管理局中药质量控制重点实验室,武汉 430075
- 2. 湖北中医药大学,武汉 430065
- 3. 中国食品药品检定研究院,北京 100050
- 折叠
摘要
Abstract
Objective To establish a determination method of polydimethylsiloxane on the surface of halogenated butyl rubber stoppers based on inductively coupled plasma optical emission spectrometry(ICP-OES).Methods The halogenated butyl rubber stoppers were ultrasonic extracted by aviation kerosene.The extraction was determined by direct injection.The effect of different radio frequency power,nebulizer flow,auxiliary gas and plasma flow rate,and ultrasound extraction time on the determi-nation of polydimethylsiloxane were studied.Results The linear range of polydimethylsiloxane was about 1.0-50 μg·mL-1 and its correlation coefficient was 0.999 9.The LOQ of polydimethylsiloxane was 0.3 μg·mL-1,the average recoveries were 90.37%-98.34%,and the relative standard deviation(RSD,n=9)were 0.64%-2.22%.Conclusion This method is sensi-tive,accurate,and can be used to determine polydimethylsiloxane on the surface of halogenated butyl rubber stoppers.关键词
卤化丁基橡胶塞/二甲基硅油/电感耦合等离子体发射光谱法Key words
Halogenated butyl rubber stoppers/Polydimethylsiloxane/Inductively coupled plasma optical emission spectrometry分类
医药卫生引用本文复制引用
陈晓莉,付蒙,王经纬,胡敏,赵霞..电感耦合等离子体发射光谱法测定药用卤化丁基橡胶塞表面硅油量[J].医药导报,2024,43(5):696-699,4.
