医药导报2024，Vol.43Issue(5)：700-705,6.DOI:10.3870/j.issn.1004-0781.2024.05.005
基于红外光谱技术结合化学计量学快速鉴别药用复合膜组合材料
Rapid Identification of Pharmaceutical Composite Film Composites Based on Infrared Spectroscopy Combined with Chemometrics
摘要
Abstract
Objective To qualitatively identify the combined materials of pharmaceutical composite films by infrared spectroscopy combined with chemometrics,and to analyse and determine the respective characteristic absorption peaks.Methods The infrared spectra of several batches of composite film samples from different manufacturers were collected by Fou-rier transform infrared spectrometer.After the raw spectra were pre-processed,the infrared spectral data were analysed by hierar-chical cluster analysis(HCA),similarity analysis and orthogonal partial least squares discriminant analysis(OPLS-DA).Results Based on the IR spectral data obtained,the samples were classified into three combinations of polyethylene(PE),pol-yester(PET)and polypropylene(PP)materials,and their respective eigenfrequency distributions were basically the same,with only differences in peak intensities.Through the auxiliary analysis of the three chemometric methods mentioned above,the classi-fication criteria were further determined when the results were consistent,which met the requirements of the study.Conclusion The present method has good resolution and allows for the rapid and effectively identify the different combination materials of pharmaceutical composite films,providing a basis for the infrared identification of the materials concerned.关键词
药用复合膜/聚酯/聚丙烯/聚乙烯/红外光谱/化学计量学Key words
Pharmaceutical composite films/Polyester/Polypropylene/Polyethylene/Infrared spectroscopy/Chemomet-rics分类
医药卫生引用本文复制引用
朱碧君,辜倩,汪元亮,熊马剑,郑国高,赵霞..基于红外光谱技术结合化学计量学快速鉴别药用复合膜组合材料[J].医药导报,2024,43(5):700-705,6.基金项目
江西省科技重点研发计划项目(20192BBGL70047) （20192BBGL70047）
中国食品药品检定研究院中青年发展研究基金项目资助(2023C6). （2023C6）
