基于红外光谱技术结合化学计量学快速鉴别药用复合膜组合材料OA北大核心CSTPCD

Objective To qualitatively identify the combined materials of pharmaceutical composite films by infrared spectroscopy combined with chemometrics,and to analyse and determine the respective characteristic absorption peaks.Methods The infrared spectra of several batches of composite film samples from different manufacturers were collected by Fou-rier transform infrared spectrometer.After the raw spectra were pre-processed,the infrared spectral data were analysed by hierar-chical cluster analysis(HCA),similarity analysis and orthogonal partial least squares discriminant analysis(OPLS-DA).Results Based on the IR spectral data obtained,the samples were classified into three combinations of polyethylene(PE),pol-yester(PET)and polypropylene(PP)materials,and their respective eigenfrequency distributions were basically the same,with only differences in peak intensities.Through the auxiliary analysis of the three chemometric methods mentioned above,the classi-fication criteria were further determined when the results were consistent,which met the requirements of the study.Conclusion The present method has good resolution and allows for the rapid and effectively identify the different combination materials of pharmaceutical composite films,providing a basis for the infrared identification of the materials concerned.