临床研究2024，Vol.32Issue(5)：13-15,3.DOI:10.12385/j.issn.2096-1278(2024)05-0013-03
注射雷珠单抗联合810 nm激光对Ⅱ区早产儿视网膜病变患儿的影响
The Impact of Intravitreal Ranibizumab Combined with 810 nm Laser on Retinopathy of Prematurity in Zone Ⅱ Premature Infants
徐利辉 1孙爽 1卢跃兵 1黄云云 1蒋瑜 1史丽英1
作者信息
- 1. 河南省儿童医院,郑州大学附属郑州儿童医院 眼科,河南 郑州 451161
- 折叠
摘要
Abstract
Objective To investigate the effect of intravitreal ranibizumab combined with 810 nm laser on the control rate of retinopathy of prematurity(ROP)in zone Ⅱ premature infants and the level of serum vascular endothelial growth factor(VEGF).Methods A retrospective analysis was conducted on clinical data of 50 cases(90 eyes)of zone Ⅱ ROP infants admitted to Henan Children's Hospital from January 2020 to June 2023.According to the treatment plan,the infants were divided into a control group(25 cases,46 eyes)and a combination group(25 cases,44 eyes).The control group received intravitreal ranibizumab treatment,while the combination group received intravitreal ranibizumab combined with 810 nm laser photocoagulation treatment.The control rates of lesions,retinal development functional indicators[full-field electroretinogram(FERG)amplitude of the b-wave in light and dark adaptation],fluorescein fundus angiography(FFA)findings before and 1 month after treatment,and serum VEGF levels were compared between the two groups.Results The lesion control rate in the combination group(93.18%)was higher than that in the control group(78.26%),with a statistically significant difference(P＜0.05).One month after treatment,the combination group showed higher rates of reduction in fluorescein leakage,regression of neovascularization,and improvement in retinal vessel tortuosity compared to the control group,with statistically significant differences(P＜0.05).Six months after treatment,the combination group had higher FERG b-wave amplitudes in light and dark adaptation than the control group,with statistically significant differences(P＜0.05).One month after treatment,the serum VEGF level in the combination group was lower than that in the control group,with a statistically significant difference(P＜0.05).Conclusion Intravitreal ranibizumab combined with 810 nm laser photocoagulation treatment can effectively promote the improvement of FFA manifestations and retinal development function in zone Ⅱ ROP infants,inhibit VEGF expression,and increase the lesion control rate.关键词
早产儿视网膜病变/雷珠单抗/810nm激光/疾病控制率Key words
retinopathy of prematurity/ranibizumab/810 nm laser/disease control rate分类
临床医学引用本文复制引用
徐利辉,孙爽,卢跃兵,黄云云,蒋瑜,史丽英..注射雷珠单抗联合810 nm激光对Ⅱ区早产儿视网膜病变患儿的影响[J].临床研究,2024,32(5):13-15,3.
