孕激素联合宫腔镜等离子电切术治疗子宫内膜息肉的临床效果OA
Clinical Efficacy of Progesterone Combined with Hysteroscopic Plasma Resection in the Treatment of Endometrial Polyps
目的 探讨孕激素联合宫腔镜等离子电切术治疗子宫内膜息肉(EP)患者的临床效果.方法 选取 2020 年 1月至 2023 年 7 月濮阳油田总医院收治的共计 90 例EP患者,以随机数字表法分成研究组(n=45)与对照组(n=45),对照组采用宫腔镜等离子电切术治疗,研究组采用孕激素联合宫腔镜等离子电切术治疗,比较两组月经量、子宫状况、实验室检查指标、不良反应及复发率.结果 两组术后 3 个月均月经量、子宫内膜厚度减少,搏动指数(PI)、阻力指数(RI)水平降低,差异有统计学意义(P<0.05),研究组月经量较对照组更少,子宫内膜厚度更薄,PI、RI水平更低,差异有统计学意义(P<0.05);两组术后 3 个月纤维蛋白原(FIB)水平下降,红细胞压积(HCT)、血红蛋白(Hb)水平升高,差异有统计学意义(P<0.05),研究组FIB水平较对照组更低,HCT、Hb水平更高,差异有统计学意义(P<0.05);研究组不良反应发生率(6.67%)低于对照组(22.22%),差异有统计学意义(P<0.05);随访 6 个月,研究组复发率(8.89%)低于对照组(26.67%),差异有统计学意义(P<0.05).结论 孕激素联合宫腔镜等离子电切术用于治疗EP,能够减少月经量,改善FIB、HCT、Hb水平,改善子宫状况,降低不良反应发生率及EP复发率.
Objective To explore the clinical efficacy of progesterone combined with hysteroscopic plasma resection in patients with endometrial polyps(EP).Methods A total of 90 EP patients treated at Puyang Oilfield General Hospital from January 2020 to July 2023 were selected.They were randomly divided into a study group(n=45)and a control group(n=45).The control group was treated with hysteroscopic plasma resection,while the study group was treated with progesterone combined with hysteroscopic plasma resection.The menstrual volume,uterine condition,laboratory examination indicators,adverse reactions,and recurrence rate were compared between the two groups.Results Three months after surgery,both groups showed a decrease in menstrual volume,reduction in endometrial thickness,and decreased pulsatility index(PI)and resistance index(RI)levels,with statistically significant differences(P<0.05).The study group had less menstrual volume,thinner endometrial thickness,and lower PI and RI levels compared to the control group,with statistically significant differences(P<0.05).Three months after surgery,both groups showed a decrease in fibrinogen(FIB)levels and an increase in hematocrit(HCT)and hemoglobin(Hb)levels,with statistically significant differences(P<0.05).The study group had lower FIB levels and higher HCT and Hb levels compared to the control group,with statistically significant differences(P<0.05).The incidence of adverse reactions in the study group(6.67%)was lower than that in the control group(22.22%),with statistically significant differences(P<0.05).At 6 months of follow-up,the recurrence rate in the study group(8.89%)was lower than that in the control group(26.67%),with statistically significant differences(P<0.05).Conclusion Progesterone combined with hysteroscopic plasma resection for the treatment of EP can reduce menstrual volume,improve FIB,HCT,and Hb levels,improve uterine condition,and reduce the incidence of adverse reactions and recurrence rate of EP.
郭子楠;王艳虹
濮阳油田总医院 妇科,河南 濮阳 457001
临床医学
子宫内膜息肉宫腔镜等离子电切术孕激素临床效果
endometrial polypshysteroscopic plasma resectionprogesteroneclinical efficacy
《临床研究》 2024 (005)
109-112 / 4
2018年度河南省医学科技攻关计划联合共建项目(2018020968).
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