湖北医药学院学报2024，Vol.43Issue(2)：147-151,5.DOI:10.13819/j.issn.2096-708X.2024.02.007
肌骨超声引导下PRP肩袖间隙注射治疗冻结肩的临床疗效及机制研究
Study on the Clinical Eeffect and Mechanism of the Treatment of Frozen Shoulder by Injecting PRP Into the Rota-tor Cuff Space Under the Guidance of MSKUS
摘要
Abstract
Objective To observe the clinical effect of platelet-rich plasma(PRP)injection into rotator cuff space guided by musculo-skeletal ultrasound(MSKUS)in the treatment of frozen shoulder,and to explore its mechanism.Methods 60 cases of frozen shoulder patients were randomly divided into a control group and a treatment group,with 30 cases in each group.The treatment group received PRP injection therapy,while the control group received betamethasone+9%sodium chloride solution injection therapy.After two courses of treatment,the Constant-Murley shoulder joint function scores,pos-terior capsular thickness(PCT),glenohumeral distance(GHD),TNF-α,IL-6 levels,and clinical efficacy were com-pared between the two groups.Results After treatment,both groups of patients showed improvements in Constant-Murley shoulder joint function assessment scores for pain,ADL,ROM,and MMT compared to before treatment(P＜0.05),with more significant improvements observed in the treatment group(P＜0.05).The levels of TNF-α and IL-6 in both groups decreased after treatment compared to before treatment(P＜0.05),with a more significant decrease observed in the treat-ment group(P＜0.05).Both groups of patients showed a decrease in PCT and an increase in GHD after treatment,with sta-tistically significant differences compared to before treatment(P＜0.05),and the improvement was more significant in the treatment group(P＜0.05).The total effective rate was 96.6%in the treatment group and 93.1%in the control group,with a statistically significant difference(P＜0.05).Conclusion The treatment of frozen shoulder with PRP under the guidance of MSKUS can relieve the pain,improve the function of shoulder joint and improve the clinical effect,which may be associ-ated with regulating TNF-α and IL-6 levels,repairing PCT and GHD tissue damage.关键词
肌骨超声/富血小板血浆/冻结肩/Constant-Murley肩关节功能评定/肩周后方关节囊厚度/盂肱距离/肿瘤坏死因子-α/白细胞介素-6Key words
Musculoskeletal ultrasound/Platelet-rich plasma/Frozen shoulder/Constant Murley shoulder function as-sessment/Posterior capsule thickness/Glenoid-brachial distance/Tumor necrosis factors-α/Interleukin-6引用本文复制引用
郑苏,王刚,赵磊,解嘉阳,谢谨,郭爽..肌骨超声引导下PRP肩袖间隙注射治疗冻结肩的临床疗效及机制研究[J].湖北医药学院学报,2024,43(2):147-151,5.基金项目
湖北省卫生健康委中医科研项目(ZY2021Q015) （ZY2021Q015）
福建中医药大学临床专项校管项目(XB2021232,XB2021233) （XB2021232,XB2021233）
