脑小血管病与认知障碍的研究进展OACSTPCD

Cerebral small vessel disease(CSVD)is a series of clinical,imaging,and pathological syndromes mainly caused by small vessel lesions,and it often has an insidious onset,diverse manifestations,and a low rate of early identification,which are the common reasons for gradual progression to cognitive impairment.It is worth noting that CSVD-related cognitive impairment is not limited to vascular cognitive impairment,and it can also involve other neurode-generative diseases such as Alzheimer disease and Parkinson disease dementia.Therefore,precise identification,early di-agnosis,and intervention are of great importance in controlling the development and damage of CSVD-related cognitive im-pairment.Given the complex pathological mechanisms and classifications of CSVD and the fact that the association be-tween CSVD and the progression of cognitive impairment cannot be neglected,this article provides a comprehensive under-standing of the etiology,pathogenesis,pathology,and imaging subtypes of CSVD and reviews the association between CSVD and various cognitive impairment diseases,so as to provide a reference for the clinical multimodal evaluation,pre-vention,and treatment of CSVD-related cognitive impairment.