中风与神经疾病杂志2024，Vol.41Issue(4)：298-304,7.DOI:10.19845/j.cnki.zfysjjbzz.2024.0059
脑小血管病与认知障碍的研究进展
Research advances in cerebral small vessel disease and cognitive impairment
摘要
Abstract
Cerebral small vessel disease(CSVD)is a series of clinical,imaging,and pathological syndromes mainly caused by small vessel lesions,and it often has an insidious onset,diverse manifestations,and a low rate of early identification,which are the common reasons for gradual progression to cognitive impairment.It is worth noting that CSVD-related cognitive impairment is not limited to vascular cognitive impairment,and it can also involve other neurode-generative diseases such as Alzheimer disease and Parkinson disease dementia.Therefore,precise identification,early di-agnosis,and intervention are of great importance in controlling the development and damage of CSVD-related cognitive im-pairment.Given the complex pathological mechanisms and classifications of CSVD and the fact that the association be-tween CSVD and the progression of cognitive impairment cannot be neglected,this article provides a comprehensive under-standing of the etiology,pathogenesis,pathology,and imaging subtypes of CSVD and reviews the association between CSVD and various cognitive impairment diseases,so as to provide a reference for the clinical multimodal evaluation,pre-vention,and treatment of CSVD-related cognitive impairment.关键词
脑小血管病/认知障碍/病理机制/防治Key words
Cerebral small vessel disease/Cognitive impairment/Pathological mechanisms/Prevention and treatment分类
医药卫生引用本文复制引用
张恒,杜怡峰..脑小血管病与认知障碍的研究进展[J].中风与神经疾病杂志,2024,41(4):298-304,7.基金项目
脑科学与类脑科学研究(2021ZD0201801,2021ZD0201808) （2021ZD0201801,2021ZD0201808）
国家自然科学基金(81861138008,82011530139) （81861138008,82011530139）
山东省自然科学基金(ZR2023QH019) （ZR2023QH019）
山东省立医院科研孵育基金(2022FY112) （2022FY112）
