中风与神经疾病杂志2024，Vol.41Issue(4)：342-348,7.DOI:10.19845/j.cnki.zfysjjbzz.2024.0067
血浆同型半胱氨酸与动脉粥样硬化早期进展的相关分析
Association of plasma homocysteine with the early progression of atherosclerosis
摘要
Abstract
Objective To investigate the risk factors for the early progression of atherosclerosis,whether hyperho-mocysteinemia(HHcy)is an independent risk factor for the early progression of atherosclerosis,and whether the reduction in homocysteine(Hcy)can delay the early progression of atherosclerosis.Methods The villagers,aged≥40 years,from Liulin Town of Hanzhong City,Shaanxi Province,China were selected for structured inquiry,carotid ultrasound examina-tion,and blood test in May 2017 and June 2020.Ultrasound examination was performed to measure carotid intima-media thickness(CIMT),carotid plaque,and carotid stenosis rate to reflect the degree of arteriosclerosis.Results A total of 500 individuals were included in the final analysis,among whom 451 had no CIMT thickening at baseline,429 had no carotid plaque at baseline,and 454 had no carotid stenosis at baseline.After 3 years of follow-up,among the 500 indi-viduals,176(35.2%)had CIMT thickening,and the multivariate analysis showed that old age,smoking,and a high level of low-density lipoprotein cholesterol(LDL-C)were independent risk factors for CIMT thickening;252(50.4%)had new-onset plaques,and the multivariate analysis showed that old age,hypertension,and high LDL-C were indepen-dent risk factors for plaque formation;231(46.2%)had new-onset carotid stenosis,and the multivariate analysis showed that old age,high LDL-C,and elevated triglyceride were independent risk factors for carotid stenosis.There were 364 patients with HHcy(≥15 μmol/L)in the initial examination,and after 3 years,119 had a reduction in Hcy,while 245 had no reduction in Hcy.After adjustment for sex,previous stroke,smoking,baseline LDL-C,baseline Hcy,and Hcy after 3 years,the multivariate analysis showed that neither HHcy nor the reduction in Hcy was associated with carotid atherosclerosis.Conclusion Old age,high LDL-C,smoking,and hypertension are the main risk factors for atherosclerosis in villagers aged≥40 years in rural areas of Hanzhong City in Shaanxi Province.There is no signifi-cant association between HHcy and carotid atherosclerosis,and the reduction in Hcy cannot delay or reverse the process of carotid atherosclerosis.关键词
动脉粥样硬化/颈动脉内膜中层厚度/颈动脉斑块/同型半胱氨酸Key words
Atherosclerosis/Carotid intima-media thickness/Carotid plaque/Homocysteine分类
医药卫生引用本文复制引用
王阳,张潇,师瑞,李扬..血浆同型半胱氨酸与动脉粥样硬化早期进展的相关分析[J].中风与神经疾病杂志,2024,41(4):342-348,7.基金项目
国家自然科学基金面上项目(82271317) （82271317）
