中风与神经疾病杂志2024，Vol.41Issue(4)：369-371,3.DOI:10.19845/j.cnki.zfysjjbzz.2024.0072
AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告
A case report of anti-NMDAR and anti-AMPAR autoimmune encephalitis with opsoclonus-myoclonus syndrome
江佳佳 1杨伊 1王文暄 1刘雅菁 1尹梓曈 1冯双浩 1李小艳 1卜晖1
作者信息
- 1. 河北医科大学第二医院,河北 石家庄 050004
- 折叠
摘要
Abstract
Opsoclonus-myoclonus syndrome(OMS)is a rare neurological syndrome associated with tumors,which is more common in children than in adults.It is characterized by involuntary,arrhythmic,chaotic,multidirectional sac-cades,usually accompanied by limb and trunk myoclonic seizures and ataxia.Case reports are even rare on OMS compli-cated by autoimmune encephalitis with overlapping antibodies against the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepro-pionic acid receptor(AMPAR)and N-methyl-D-aspartate receptor(NMDAR),and its clinical manifestations and treat-ment are poorly understood.We report a case of autoimmune encephalitis with OMS positive for both NMDAR and AMPAR antibodies,and also review relevant literature to help improve the understanding of the condition.关键词
自身免疫性脑炎/α-氨基-3-羟基-5-甲基-4-异唑丙酸/N-甲基-D-天冬氨酸/边缘性脑炎/重叠综合征/眼阵挛-肌阵挛综合征Key words
Autoimmune encephalitis/Alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-D-aspartate/Limbic encephalitis/Overlap syndrome/Opsoclonus-myoclonus syndrome分类
医药卫生引用本文复制引用
江佳佳,杨伊,王文暄,刘雅菁,尹梓曈,冯双浩,李小艳,卜晖..AMPA与NMDA抗体重叠的自身免疫性脑炎合并眼阵挛-肌阵挛综合征1例报告[J].中风与神经疾病杂志,2024,41(4):369-371,3.
