中风与神经疾病杂志2024，Vol.41Issue(4)：372-376,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0073
铁死亡的发生机制及其在脑出血中的作用与相关药物治疗研究进展
Research advances in the mechanism of ferroptosis,its role in intracerebral hemorrhage,and related drug thera-pies
魏阳阳 1王钦鹏 1蔡珂 1李婷婷 1梁成1
作者信息
- 1. 兰州大学第二临床医学院,甘肃 兰州 730000||兰州大学第二医院,甘肃 兰州 730030
- 折叠
摘要
Abstract
Ferroptosis is a newly discovered iron-dependent form of non-apoptotic cell death and is involved in the pathological process of many diseases.Intracerebral hemorrhage is a disease with high morbidity,mortality,and disability rates and is a common acute and critical illness in the department of neurology,and it often has a poor prognosis and greatly threatens human health.Primary brain tissue injury caused by intracerebral hemorrhage and secondary injury asso-ciated with cytotoxicity,neuroinflammation,and oxidative stress are the main reasons leading to poor prognosis,among which secondary brain injury after intracerebral hemorrhage is a difficulty in clinical treatment at present.Studies have shown that ferroptosis is closely associated with the course of secondary brain injury after intracerebral hemorrhage.In-depth research on the mechanism of ferroptosis after intracerebral hemorrhage and the prospect of drug therapies will pro-vide new ideas and new targets for the diagnosis and treatment of secondary brain injury after intracerebral hemorrhage.关键词
铁死亡/脑出血/继发性脑损伤Key words
Ferroptosis/Intracerebral hemorrhage/Secondary brain injury分类
医药卫生引用本文复制引用
魏阳阳,王钦鹏,蔡珂,李婷婷,梁成..铁死亡的发生机制及其在脑出血中的作用与相关药物治疗研究进展[J].中风与神经疾病杂志,2024,41(4):372-376,5.
