中风与神经疾病杂志2024，Vol.41Issue(4)：381-384,4.DOI:10.19845/j.cnki.zfysjjbzz.2024.0075
铜稳态失调在肌萎缩侧索硬化发病机制中的研究进展
Research advances in copper homeostasis disorder in the pathogenesis of amyotrophic lateral sclerosis
摘要
Abstract
Copper plays an important role in maintaining the normal metabolic function of cells and participates in a variety of physiological processes in cells,including cell respiration,neuropeptide processing,and iron transport,and therefore,it is of great significance to maintain copper homeostasis.In the central nervous system,copper homeostasis is involved in the regulation of synaptic function and the formation of myelin sheath,and copper homeostasis disorder is closely associated with the development of various neurodegenerative diseases.Recent studies have shown that copper ho-meostasis disorder caused by the mutation of ATPase copper transporting α may lead to the development and progression of amyotrophic lateral sclerosis(ALS).This article reviews the research advances in copper homeostasis disorder in the pathogenesis of ALS and points out that maintaining copper homeostasis may provide a new target for the treatment of ALS.关键词
肌萎缩侧索硬化/铜稳态/铜转运ATP酶αKey words
Amyotrophic lateral sclerosis/Copper homeostasis/ATPase copper transporting α分类
医药卫生引用本文复制引用
张莹,色瑶,姜宏佺..铜稳态失调在肌萎缩侧索硬化发病机制中的研究进展[J].中风与神经疾病杂志,2024,41(4):381-384,4.基金项目
黑龙江省自然科学基金优秀青年项目(YQ2020H013) （YQ2020H013）
国家自然科学基金青年科学基金(81601102) （81601102）
黑龙江省博士后启动基金(LBH-Q19128) （LBH-Q19128）
中国初级卫生保健基金会(2022HX034) （2022HX034）
