中国病理生理杂志2024，Vol.40Issue(4)：602-609,8.DOI:10.3969/j.issn.1000-4718.2024.04.004
蓝斑核GABA表达神经元影响体温
Effect of GABA-expressing neurons in locus coeruleus on body tempera-ture
摘要
Abstract
AIM:The locus coeruleus plays a crucial role in energy homeostasis,notably through its γ-amino-butyric acid(GABA)neurons involved in body temperature regulation.However,the specific function of locus coeruleus GABA-expressing neurons in regulating body temperature is not fully understood.This study aims to investigate the role of locus coeruleus GABA-expressing neurons in thermoregulation and the underlying mechanisms.METHODS:Chemoge-netic techniques were employed to selectively inhibit GABAergic neuron activity in the locus coeruleus.Subsequent obser-vations included changes in core body temperature,food intake,glucose tolerance,and insulin sensitivity in mice.Fur-thermore,the expression of mitochondrial uncoupling protein 1(UCP1)in interscapular brown adipose tissue(IBAT)was detected by Western blot.RESULTS:The inhibition of locus coeruleus GABA-expressing neurons led to a significant re-duction in core body temperature and IBAT temperature in fasted mice(P<0.05),along with a marked increase in UCP1 expression in IBAT(P<0.05).CONCLUSION:The findings of this study reveal the significant influence of locus coeru-leus GABA-expressing neurons on body temperature regulation in mice,advancing the understanding of how the central nervous system impacts thermoregulation and energy metabolism by modulating specific neuronal groups.This contributes to the broader comprehension of related physiological mechanisms.关键词
蓝斑核/γ-氨基丁酸/肩胛间棕色脂肪组织/解偶联蛋白1Key words
locus coeruleus/γ-aminobutyric acid/interscapular brown adipose tissue/uncoupling protein 1分类
医药卫生引用本文复制引用
李嘉成,杜晨光,苏布登格日勒,刘昊东,李鹏辉,樊奇,王星,闫睿,贺炀,张明,周鑫..蓝斑核GABA表达神经元影响体温[J].中国病理生理杂志,2024,40(4):602-609,8.基金项目
国家自然科学基金资助项目(No.32060204) （No.32060204）
内蒙古科技攻关计划(No.2021GG0199) （No.2021GG0199）
内蒙古自然科学基金资助项目(No.2020MS03035) （No.2020MS03035）
内蒙古自治区教育厅高等学校科学研究项目(No.NJZY22535) （No.NJZY22535）
内蒙古自治区直属高校基本科研业务费项目(No.BR220150) （No.BR220150）
内蒙古自治区高等学校科学研究重点项目(No.NJZZ22529) （No.NJZZ22529）
内蒙古自治区教育厅高等学校科学研究项目(No.NJZY23120) （No.NJZY23120）
