中国病理生理杂志2024，Vol.40Issue(4)：735-741,7.DOI:10.3969/j.issn.1000-4718.2024.04.020
组蛋白乳酸化修饰在结直肠癌发展中作用的研究进展
Progress in role of histone lactylation in development of colorectal cancer
摘要
Abstract
Colorectal cancer is a malignant tumor with high morbidity and mortality worldwide.Histone lacty-lation,a new protein post-translational modification,can be used as a potential biomarker for the diagnosis and treatment of colorectal cancer by regulating the structure of chromatin and gene transcription.This paper focuses on the role and mechanism of histone lactylation modification in the development of colorectal cancer.Additionally,the latest research progress and clinical experimental results are presented.This paper further shows that histone lactylation manipulates gene expression by affecting nuclear transcription factors and other epigenetic modifications involved in various life processes and subsequently regulates cell physiological function,revealing its regulatory mechanism and the functions of related en-zymes.The relationships between histone lactylation and energy metabolic pathways such as glycolysis and oxidative phos-phorylation are discussed in detail.The final part of this paper illustrates the important role of this modification in terms of the occurrence and development of colorectal cancer,cell metabolic reprogramming,and epigenetic regulation,supporting the clinical application of the use of histone lactylation as a biomarker.关键词
结直肠癌/组蛋白乳酸化/表观遗传学/代谢重编程Key words
colorectal cancer/histone lactylation/epigenetics/metabolic reprogramming分类
医药卫生引用本文复制引用
韩磊,陆玉成,韦志永,姚宁宁..组蛋白乳酸化修饰在结直肠癌发展中作用的研究进展[J].中国病理生理杂志,2024,40(4):735-741,7.基金项目
山东省自然科学基金资助项目(No.ZR2023MH292) （No.ZR2023MH292）
徐州医科大学附属医院科技发展基金(No.XYFM202348) （No.XYFM202348）
