中国病理生理杂志2024，Vol.40Issue(4)：742-747,6.DOI:10.3969/j.issn.1000-4718.2024.04.021
蛋白质乳酸化修饰调控疾病发生的研究进展
Advances in regulation of disease development by protein lactylation modifications
摘要
Abstract
Known as a classic product of glucose metabolism,lactic acid has been regarded as a metabolic waste.However,it wasn't until the discovery of Warburg effect in tumors that researchers refocused on the role of lactic acid in cells.Being a kind of signaling molecule with multiple functions,lactic acid is a key metabolic product connecting gly-colysis and oxidative phosphorylation,and it also has non-metabolic activity.Recent studies have shown that lactic acid can be used as a substrate to participate in a novel post-translational modification of proteins,known as protein lactylation.It can be involved in many kinds of diseases,and plays an important role in immune regulation and homeostasis mainte-nance.This paper briefly describes and summarizes the important role of lactylation modification in the developmental mecha-nisms of diseases such as tumors,inflammation,neuropsychiatric diseases,cardiocerebrovascular diseases,and so on.关键词
乳酸/乳酸化/肿瘤/炎症Key words
lactic acid/lactylation/tumor/inflammation分类
医药卫生引用本文复制引用
关铭悦,刘爽,张雪..蛋白质乳酸化修饰调控疾病发生的研究进展[J].中国病理生理杂志,2024,40(4):742-747,6.基金项目
黑龙江省教育厅基本科研业务费基础研究项目(No.2020-KYYWF-0280) （No.2020-KYYWF-0280）
