中国病理生理杂志2024，Vol.40Issue(4)：755-762,8.DOI:10.3969/j.issn.1000-4718.2024.04.023
微小RNA在肾组织纤维化中作用的研究进展
Progress in role of microRNA in renal fibrosis
摘要
Abstract
Progressive renal fibrosis is the hallmark of chronic kidney disease,which possesses heavy public health burden globally.Both diabetic and non-diabetic kidney diseases are the major causes for development of chronic kidney disease.MicroRNAs(miRNAs),short noncoding RNAs,exert their regulatory roles at a post-transcription level and have been studied for renal fibrosis progression in diabetic and non-diabetic nephropathy.In this review,the pattern of miRNA expression alternations in diabetic and non-diabetic kidney diseases is summarized followed by discussion on the roles of miRNAs in renal fibrosis through interacting with various signaling pathways,such as transforming growth factor-β,nuclear factor-κB,Janus kinase/signal transducer and activator of transcription,tissue inhibitor of metalloproteinase 3,and SRY-box transcription factor 6.The potential of physical exercise in protection of renal dysfunction by regulating miRNAs is briefly discussed.关键词
微小RNA/肾纤维化/转化生长因子β/核因子κB/JAK/STAT信号通路Key words
microRNA/renal fibrosis/transforming growth factor-β/nuclear factor-κB/JAK/STAT pathway分类
医药卫生引用本文复制引用
李君灵..微小RNA在肾组织纤维化中作用的研究进展[J].中国病理生理杂志,2024,40(4):755-762,8.基金项目
国家自然科学基金资助项目(No.22176116) （No.22176116）
教育部人文社科研究规划基金项目(No.21YJA890017) （No.21YJA890017）
山西省自然科学基金资助项目(No.2012011036-4) （No.2012011036-4）
