中国动物检疫2024，Vol.41Issue(4)：71-75,102,6.DOI:10.3969/j.issn.1005-944X.2024.04.014
尼帕病毒G蛋白的结构与功能及其应用研究进展
Research Progress in the Structure,Functions and Application of G Protein of Nipah Virus
摘要
Abstract
Nipah virus(NiV)is a highly lethal zoonotic paramyxovirus causing severe respiratory diseases and Nipah viral encephalitis,but no clinically approved vaccines or therapeutic drugs have been available for human infection.Six proteins are encoded by NiV genome,including G protein that participates in virus invasion and other processes,and can stimulate organisms to produce neutralizing antibodies as being a receptor protein and an important immunogenic protein,potentially contributing to researches on NiV pathogenicity and the development of vaccines and detection technologies.In the study,the structure and physiological functions of NiV G protein as well as the research status of vaccines and detection technologies based on G protein were reviewed,and the direction to researches on its application was prospected,with a view to providing an important reference for clarifying the pathogenic mechanism of NiV and for the development of relevant vaccines.关键词
尼帕病毒/G蛋白/结构与功能/疫苗/检测技术Key words
NiV/G protein/structure and function/vaccine/detection technology分类
农业科技引用本文复制引用
陈舒瑜,付环茹,李家玉,黄瑜,万春和..尼帕病毒G蛋白的结构与功能及其应用研究进展[J].中国动物检疫,2024,41(4):71-75,102,6.基金项目
国家现代农业产业技术体系资助项目(CARS-42-18) （CARS-42-18）
福建省科技计划项目(2020J06029,2021R1026006) （2020J06029,2021R1026006）
福建省农业科学院科技计划项目(DWHZ2024-13,CXTD2021005-1) （DWHZ2024-13,CXTD2021005-1）
