中国动物检疫2024，Vol.41Issue(4)：76-83,8.DOI:10.3969/j.issn.1005-944X.2024.04.015
群体感应核心调控子OpaR和AphA对副溶血弧菌生物学功能及毒力基因调控的研究进展
Research Progress in the Regulation of Biological Functions and Virulence Genes of Vibrio parahaemolyticus by Quorum-sensing Core Regulators OpaR and AphA
摘要
Abstract
Quorum sensing(QS)is a common signaling mechanism among bacteria,affecting bacterial biological functions and expression of virulence genes.Vibrio parahaemolyticus is widely distributed in marine environment,seriously affecting global aquaculture industry.OpaR and AphA are the core regulators of the QS system of Vibrio parahaemolyticus,the former mainly plays a regulatory role at high cell density(HCD),while the latter at low cell density(LCD).The two regulators are involved in regulating various biological functions including biofilm formation and motility capacity,playing an important role in the pathogenicity of Vibrio parahaemolyticus.In the study,the transcriptional expression of OpaR,AphA and relevant genes at different bacterial densities as well as their regulation for bacterial biological functions and virulence gene expression were described,then the pathogenic mechanism of Vibrio parahaemolyticus at the molecular level was further analyzed,expecting to provide a reference for future prevention and control of the disease.关键词
副溶血弧菌/群体感应系统/OpaR/AphAKey words
Vibrio parahaemolyticus/quorum-sensing system/OpaR/AphA分类
农业科技引用本文复制引用
谢景媚,王利莹,王国浩,杨倩,董宣..群体感应核心调控子OpaR和AphA对副溶血弧菌生物学功能及毒力基因调控的研究进展[J].中国动物检疫,2024,41(4):76-83,8.基金项目
中国水产科学研究院黄海水产研究所基本科研业务费资助项目(20603022022005) （20603022022005）
青岛市市南区科技计划资助项目(2022-2-027-ZH) （2022-2-027-ZH）
青岛市自然科学基金项目(23-2-1-181-zyyd-jch) （23-2-1-181-zyyd-jch）
中国水产科学研究院基本科研业务费资助项目(2023TD42) （2023TD42）
