摘要
Abstract
Objective:To analyze the treatment outcomes and risk factors among patients with rifampicin-sensitive tuberculosis-diabetes mellitus comorbidity(PTB-DM)patients in Yunnan Province,to provide evidence for improving the effect of anti-tuberculosis treatment for PTB-DM by.Methods:The medical data of PTB-DM patients registered in Yunnan Province from January 1,2017 to December 31,2021 were obtained through the"Monitoring Report Management System"of the"China Disease Prevention and Control Information System"subsystem,including sociodemographic information,tuberculosis diagnosis,anti-tuberculosis treatment and judgment of the treatment,3984 cases were finally included.The effectiveness of anti-tuberculosis treatment in PTB-DM patients was analyzed,and the risk factors of the treatment outcome were analyzed using Cox regression model.Results:The success rate of anti-tuberculosis treatment in 3984 PTB-DM patients was 89.36％(3560/3984),the incidence of adverse treatment outcomes of 10.64％(424/3984),the mortality was 4.27％(170/3984),and 2.46％(98/3984)were lost during treatment,with failure of 2.31％(92/3984)and discontinuation of treatment due to adverse drug reactions of 1.61％(64/3984).Of adverse outcomes,44.22％(179/424)occurred in the first 2 months of treatment.Cox regression model analysis showed that individuals aged≥65 had a higher risk of adverse treatment outcomes compared to those who aged＜35(HR=2.612,95％CI:1.483-4.601);the risk of adverse treatment outcomes in retreated patients was 1.405 times higher than that in newly treated patients(95％CI:1.072-1.843),and the risk of adverse treatment outcomes in pathogen positive patients was 1.473 times higher than that in other patients(95％CI:1.183-1.834).Conclusion:The effectiveness of anti-tuberculosis treatment for PTB-DM patients in Yunnan Province is not satisfactory,and attention should be paid to PTB-DM patients,especially elderly people aged 65 and above,re-treated,and pathogen-positive patients.During the anti-tuberculosis treatment,monitoring of treatment effectiveness and health management should be carried out,and timely intervention should be given.关键词
结核,肺/糖尿病/共病现象/治疗结果/因素分析,统计学Key words
Tuberculosis,pulmonary/Diabetes mellitus/Comorbidity/Treatment outcome/Factor analysis,statistical分类
医药卫生
