中国防痨杂志2024，Vol.46Issue(5)：525-530,6.DOI:10.19982/j.issn.1000-6621.20230402
耐药肺结核患者密切接触者结核分枝杆菌潜伏感染危险因素分析
Risk factors of latent tuberculosis infection among close contacts of drug-resistant pulmonary tuberculosis patients
摘要
Abstract
Objective:To explore the situation and risk factors of latent tuberculosis infection(LTBI)in close contacts of drug-resistant pulmonary tuberculosis patients.Methods:Using a prospective research method,306 close contacts of 154 drug-resistant pulmonary tuberculosis(including rifampicin resistant pulmonary tuberculosis and multidrug-resistant pulmonary tuberculosis)patients admitted to the Wenzhou Central Hospital from July 2020 to January 2022 were selected as the study subjects.Collected information included the sociodemographic characteristics,history of BCG vaccination,disease history,and contact with indicated cases of the research subjects;in addition,HIV antibody screening,chest CT scan,T-SPOT.TB and/or PPD test,etc.were conducted.The LTBI situation of the research subjects was investigated,and logistic regression models were used to analyze the influencing factors of their occurrence of LTBI.Results:The LTBI rate among the study subjects was 18.6％(57/306).The results of multivariate analysis showed that,for the close contacts,aged ≥ 40 years,female,physical workers,and those with clinical symptoms such as cough and sputum in the indication case were at a higher risk of developing LTBI(OR(95％CI)values of 6.501(1.371-30.827),2.961(1.472-5.956),2.716(1.368-5.391),3.100(1.278-7.521),and 3.065(1.336-7.031),respectively);family monthly income≥RMB 5000 yuan was a protective factor for close contacts to develop LTBI(OR(95％CI)=0.308(0.156-0.607)).Conclusion:Close contacts of drug-resistant pulmonary tuberculosis patients have a higher LTBI rate.Elderly,female,physically active workers,low-income individuals,as well as close contacts with relapsed drug-resistant pulmonary tuberculosis patients and drug-resistant pulmonary tuberculosis patients with clinical symptoms such as cough and sputum,are high-risk population for latent infection.关键词
结核,肺/抗药性,细菌/接触者追踪/感染/因素分析,统计学Key words
Tuberculosis,pulmonary/Drug resistance,bacterial/Contact tracing/Infection/Factor analysis,statistical分类
医药卫生引用本文复制引用
叶新春,施伎蝉,刘赛朵,程芳,蒋贤高,宁洪叶,吴正兴,周月影,邱超超,潘宁..耐药肺结核患者密切接触者结核分枝杆菌潜伏感染危险因素分析[J].中国防痨杂志,2024,46(5):525-530,6.基金项目
耐多药结核病患者密切接触者观察性研究(Y20211148) Observational Study of Close Contacts of Patients with Multidrug-Resistant Tuberculosis(Y20211148) （Y20211148）
