中国防痨杂志2024，Vol.46Issue(5)：531-537,7.DOI:10.19982/j.issn.1000-6621.20240029
2016-2022年安徽省结核病耐药监测结果分析
Analysis of Mycobacterium tuberculosis drug resistance monitoring in Anhui Province from 2016 to 2022
摘要
Abstract
Objective:To analyze the change trend of drug resistance spectrum of Mycobacterium tuberculosis isolated from four national drug resistance monitoring sites in Anhui Province from 2016 to 2022,and then to understand the prevalence and control effect of tuberculosis and drug-resistant tuberculosis in Anhui Province.Methods:A total of 3073 laboratory-confirmed pulmonary tuberculosis patients,who were continuously enrolled from four drug resistance surveillance sites between 2016 and 2022,were included in the study.General information of the patients was collected,and sputum specimens were collected for isolation and cultured.Strain identification was performed on the cultured isolates,and a total of 2336 strains of Mycobacterium tuberculosis were obtained.Drug susceptibility testing was performed on the Mycobacterium tuberculosis strains using the proportion method for six anti-tuberculosis drugs(isoniazid(INH),rifampicin(RFP),streptomycin(Sm),ethambutol(EMB),ofloxacin(Ofx),and kanamycin(Km).Results:Among the 2336 strains of Mycobacterium tuberculosis,1893 strains(81.04％)were sensitive to all the six anti-tuberculosis drugs,and 443 strains were resistant to at least one or more anti-tuberculosis drugs,with a drug resistance rate of 18.96％(443/2336),of which 16.80％(348/2071)were newly treated,35.85％(95/265)were retreated,and 98(4.20％)were multidrug resistant.Among the six anti-tuberculosis drugs,the prevalence of single resistance to anti-tuberculosis drugs were decreased from INH(10.55％,236/2336)to Sm(8.18％,183/2336),Ofx(6.53％,146/2336),RFP(5.95％,133/2336),EMB(2.37％,53/2336),Km(1.97％,44/2336).The resistance rates to Ofx,INH,EMB and Km showed a downward trend from 2016 to 2022(the resistance rates of Ofx,INH,EMB and Km were 10.49％(30/286),12.24％(35/286),1.75％(5/286)and 2.45％(7/286)in 2016,respectively;3.89％(18/463),9.29％(43/463),0.86％(4/463),1.08％(5/463)in 2022);x2trend values were 16.964,15.989,15.798,and 26.075,respectively,all Ps＜0.05).The drug resistance rate and multidrug-resistance rate of newly diagnosed patients(22.76％(56/246)and 6.50％(16/246)in 2016,14.15％(60/424)and 1.89％(8/424)in 2022)also showed a downward trend(x2trend=14.445,16.688,All Ps＜0.05).Among different age groups,the drug resistance rate of Mycobacterium tuberculosis strains in the 40-59 years old group was the highest(22.74％,146/642).Conclusion:The situation of drug resistance tuberculosis is still serious in Anhui province.More attention should be paid to drug resistance in retreatment patients,people aged 40-59 years and patients living in urban areas.关键词
分枝杆菌,结核/抗药性,细菌/人群监测Key words
Mycobacterium tuberculosis/Drug resistance,bacterial/Population surveillance分类
医药卫生引用本文复制引用
包训迪,梁锁,李军,叶倩,吴丹丹,王舒,李跃,丁运生,刘洁..2016-2022年安徽省结核病耐药监测结果分析[J].中国防痨杂志,2024,46(5):531-537,7.基金项目
安徽省胸科医院科研项目(2020kj018B) Scientific Research Project of Anhui Provincial Chest Hospital(2020kj018B) （2020kj018B）
