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湖南省细菌耐药监测网2012-2021年克雷伯菌属细菌的耐药性变迁

豆清娅杨怀德袁红霞郑铭任南吴安华黄勋任碧琼陈丽华付陈超李晨李艳明刘君宁兴旺石国民邬靖敏

中国感染控制杂志2024，Vol.23Issue(4)：421-428,8.

中国感染控制杂志2024，Vol.23Issue(4)：421-428,8.DOI:10.12138/j.issn.1671-9638.20245410

湖南省细菌耐药监测网2012-2021年克雷伯菌属细菌的耐药性变迁

Changes in antimicrobial resistance of Klebsiella spp.,Hunan Province Antimicrobial Resistance Surveillance System,2012-2021

豆清娅 ¹杨怀德 ²袁红霞 ³郑铭 ⁴任南 ⁵吴安华 ⁵黄勋 ⁵任碧琼 ⁶陈丽华 ⁷付陈超 ⁴李晨 ⁸李艳明 ⁹刘君 ¹⁰宁兴旺 ¹¹石国民 ¹²邬靖敏¹³

作者信息

1. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008
2. 张家界市人民医院检验科,湖南张家界 427000
3. 郴州市第一人民医院检验医学中心,湖南郴州 423000
4. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008
5. 中南大学湘雅医院医院感染控制中心,湖南长沙 410008||国家老年疾病临床医学研究中心(湘雅医院),湖南长沙 410008||湖南省细菌耐药监测网办公室,湖南长沙 410008||湖南省医院感染管理质量控制中心,湖南长沙 410008
6. 湖南省第二人民医院(湖南省临床检验质量控制中心),湖南长沙 410007
7. 中南大学湘雅三医院检验科,湖南长沙 410013
8. 浏阳市中医医院检验科,湖南浏阳 410300
9. 中南大学湘雅医院检验科,湖南长沙 410008
10. 湘潭市中心医院检验科,湖南湘潭 411100
11. 湖南中医药大学第一附属医院医学检验与病理中心,湖南长沙 410011
12. 长沙市中心医院检验科,湖南长沙 410004
13. 长沙市第一医院检验科,湖南长沙 410005
折叠

摘要

Abstract

Objective To investigate the change in antimicrobial resistance of all Klebsiella spp.and Klebsiella spp.isolated from pediatric patients in Hunan Province,provide evidence for rational use of antimicrobial agents in the medical institutions in this area.Methods Data about Klebsiella spp.from Hunan Province Antimicrobial Re-sistance Surveillance System in 2012-2021 were analyzed,and the results were judged according to M100 32nd edi-tion standard of American Clinical and Laboratory Standards Institute(CLSI),WHONET 5.6 software was used to statistically analyze the results.Results A total of 361 539 Klebsiella spp.strains were isolated from hospitals in Hunan Province Antimicrobial Resistance Surveillance System in 2012-2021,Klebsiella pneumoniae accounted for 86.7％,and strains were mainly from respiratory tract specimens(66.5％).The resistance rate of Klebsiella spp.to imipenem and meropenem were about 10.0％in 2015-2021.The resistance rate to tigecycline decreased,with a resistance rate of 7.1％in 2012-2013 and an annual average resistance rate＜4.0％in 2018-2021.The resistance rate of bacteria to cefoperazone/sulbactam increased significantly in 2012-2021,with a rate of 13.3％in 2020-2021.Carbapenems resistance rates of Klebsiella spp.from pediatric patients in 2015-2021 were 3.5％-8.6％,and the resistance rates to tigecycline were all ≤3.8％in 2012-2021.The detection rates of carbapenem-resistant Klebsiella spp.in newborns,children aged 29 days-14 years,adults and elderly patients in 2020-2021 were 4.7％,3.9％,9.5％and 10.2％,respectively.Conclusion The resistance rates of Klebsiella spp.to carbapene-ms were low in 2012-2021,tigecycline-resistant strains have emerged,which should be paid attention to,antimi-crobial agents should be used rationally to prevent and control the occurrence of healthcare-associated infection.

关键词

克雷伯菌属/肺炎克雷伯菌/碳青霉烯类耐药/耐药性/监测/湖南省细菌耐药监测网

Key words

Klebsiella spp./Klebsiella pneumoniae/carbapenem resistance/antimicrobial resistance/survei-llance/Hunan Province Antimicrobial Resistance Surveillance System

分类

医药卫生

引用本文复制引用

豆清娅,杨怀德,袁红霞,郑铭,任南,吴安华,黄勋,任碧琼,陈丽华,付陈超,李晨,李艳明,刘君,宁兴旺,石国民,邬靖敏..湖南省细菌耐药监测网2012-2021年克雷伯菌属细菌的耐药性变迁[J].中国感染控制杂志,2024,23(4):421-428,8.

基金项目

湖南省自然科学基金资助项目(2021JJ40980) （2021JJ40980）

"感·动中国"医疗机构感染预防与控制科研项目(GY2023013-A) （GY2023013-A）

中国感染控制杂志

OA北大核心CSTPCD

ISSN：1671-9638

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