中国感染控制杂志2024，Vol.23Issue(4)：448-457,10.DOI:10.12138/j.issn.1671-9638.20245412
湖南省细菌耐药监测网2012-2021年尿标本分离细菌耐药监测报告
Antimicrobial resistance of bacteria isolated from urine specimens:sur-veillance report from Hunan Province Antimicrobial Resistance Surveillance System,2012-2021
摘要
Abstract
Objective To understand the distribution and antimicrobial resistance of bacteria from clinical urine specimens in Hunan Province,and provide scientific basis for anti-infection treatment of patients with urinary tract infection(UTI).Methods Bacterial resistance surveillance was carried out according to the technical scheme re-quirements of China Antimicrobial Resistance Surveillance System,antimicrobial susceptibility testing results were judged based on standard of American Clinical and Laboratory Standards Institute,data about strains and antimicro-bial resistance of bacteria from urine specimens reported by member units of Hunan Province Antimicrobial Resis-tance Surveillance System in 2012-2021 were analyzed with WHONET 5.6 software.Results A total of 379 330 strains of bacteria were isolated from urine specimens in 2012-2021,Gram-negative and Gram-positive bacteria ac-counted for 75.3％(72.4％-76.0％)and 24.7％(24.0％-27.6％),respectively.The top 5 Gram-negative bac-teria were Escherichia coli(48.3％),Klebsiella pneumoniae(8.4％),Proteus mirabilis(3.3％),Pseudomonas aeruginosa(3.0％)and Enterobacter cloacae(1.6％).The top 5 Gram-positive bacteria were Enterococcus faecium(8.1％),Enterococcus faecalis(6.6％),Staphylococcus epidermidis(1.9％),Staphylococcus aureus(1.9％)and Staphylococcus haemolyticus(1.4％).The constituent of bacteria isolated from urine specimens of patients in different gender and age groups were different.Escherichia coli ranked first,accounting for 34.8％and 57.2％in males and females,respectively,as well as 49.0％and 34.4％in adults and children,respectively.Escherichia coli maintained high susceptibility to carbapenems,amikacin,tigecycline,cefoperazone/sulbactam and furantoin,with resistance rate＜10％,while resistance to cefazolin,cefuroxime,ceftriaxone,cefotaxime and quinolones were rela-tively higher,with resistance rate＞48％;resistance rates to ceftazidime,ceftriaxone,cefotaxime,cefepime and az-treonam presented decreased trend(all P＜0.001).Klebsiella pneumoniae maintained higher susceptibility to car-bapenems,amikacin and tigecycline,with resistance rate＜11％,resistance rate to quinolones was much lower than that of Escherichia coli.Enterococcus faecium and Enterococcus faecalis maintained high susceptibility to vancomy-cin,teicoplanin and linezolid,with resistance rates＜5％;resistance rate of Enterococcus faecalis to ampicillin and furantoin was＜15％.Except for linezolid and minocycline,resistance rates of Enterococcus faecium to the other tested antimicrobial agents were all higher than Enterococcus faecalis.No Staphylococcus aureus was found to be resistant to vancomycin,linezolid and teicoplanin.Conclusion Escherichia coli is the main bacteria isolated from urine specimens from various member units of Hunan Province Antimicrobial Resistance Surveillance System.In early empirical treatment,clinical antimicrobial should be targetedly used as early as possible based on bacterial identification and antimicrobial susceptibility testing results,so as to improve treatment effectiveness and slow down the emergence of antimicrobial resistance.关键词
尿路感染/抗菌药物/耐药性/监测/湖南省细菌耐药监测网Key words
urinary tract infection/antimicrobial agent/antimicrobial resistance/surveillance/Hunan Province Antimicrobial Resistance Surveillance System分类
医药卫生引用本文复制引用
税剑,郑铭,任南,吴安华,黄勋,付陈超,石国民,陈丽华,李晨,李艳明,刘君,宁兴旺,邬靖敏,杨怀德,袁红霞..湖南省细菌耐药监测网2012-2021年尿标本分离细菌耐药监测报告[J].中国感染控制杂志,2024,23(4):448-457,10.基金项目
湖南省自然科学基金项目(2021JJ40624) （2021JJ40624）
湖南省卫生健康委科研计划项目(202111000032) （202111000032）
