中国感染控制杂志2024，Vol.23Issue(4)：482-487,6.DOI:10.12138/j.issn.1671-9638.20244830
111例侵袭性肺曲霉病(IPA)的临床特征及预后风险因素
Clinical characteristics and prognostic risk factors of 111 cases of invasive pulmonary aspergillosis
摘要
Abstract
Objective To explore the clinical characteristics,laboratory examination and prognostic risk factors of invasive pulmonary aspergillosis(IPA).Methods Clinical data of IP A patients in a hospital from September 2020 to June 2023 were retrospectively analyzed.Clinical characteristics and prognostic risk factors of patients were ana-lyzed.Results A total of 111 patients with IPA were analyzed,aged(68.8±12.5)years old,mainly male(63.1％),and were mainly distributed in the department of respiratory diseases,intensive care unit(ICU),departments of he-matology and infectious diseases,accounting for 75.6％in total.The common Aspergillus in IPA were Aspergillus fumigatusi Aspergillus flavus and Aspergillus niger,accounting for 67.6％,19.8％and 4.5％respectively.The positive rates of(1,3)-β-D-glucan antigen test(G test)and galactomannan antigen test(GM test)for bronchoalveo-lar lavage fluid(BALF)were 73.7％and 68.0％,respectively.Of 111 IPA patients,32(28.8％)had poor prog-nosis and 25(22.5％)were complicated with viral infection.Multivariate logistic regression analysis showed that combined with viral infection(OR[95％CI]:4.535[1.385-14.846],P=0.012),glucocorticoid use history for 3 consecutive weeks(OR[95％CI]:9.128[2.293-36.341],P=0.002),mechanical ventilation(OR[95％CI]:4.690[1.100-19.990],P=0.037)and indwelling urinary catheter(OR[95％CI]:7.144[1.345-37.950],P=0.021)were independent risk factors for poor prognosis in IPA patients.Conclusion Multiple factors are related to the poor prognosis of IPA,and multiple methods should be combined to perform early identification and rational treatment for improving patient prognosis,corresponding preventive measures should be taken to avoid the occur-rence of healthcare-associated infection.关键词
肺曲霉病/IPA/临床特征/预后风险因素Key words
pulmonary aspergillosis/IPA/clinical characteristic/prognostic risk factor分类
医药卫生引用本文复制引用
叶乃芳,龚真,唐伟,李昕,储雯雯,刘周,周强..111例侵袭性肺曲霉病(IPA)的临床特征及预后风险因素[J].中国感染控制杂志,2024,23(4):482-487,6.基金项目
安徽医科大学青年自然科学基金(2020xkj031) （2020xkj031）
安徽省高校自然科学研究项目(KJ2021ZD0029) （KJ2021ZD0029）
